ArticleBMC gastroenterology2023
Impact of comorbidities on hospital mortality in patients with acute pancreatitis: a population-based study of 110,021 patients.
Article in BMC gastroenterology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 23 citations in OpenAlex.
- Atrial fibrillation and cardiovascular comorbidity burden as predictors of in-hospital mortality in acute pancreatitis: A National Inpatient Sample analysis of 1.9 million hospitalizations.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
- Rural-urban disparities in acute pancreatitis outcomes: A retrospective cohort study using the National Inpatient Sample (2016-2021).Medicine · 2026Article
- Prognostic value of inflammatory biochemical markers (IL-8, PCT, CRP) for cardiovascular disease in patients with pancreatitis.Journal of medical biochemistry · 2026Article
- Association between the Fibrosis-4 index and mortality risk in acute pancreatitis.Frontiers in medicine · 2026Article
- High concentrations of L-lysine cause mitochondrial damage and necrosis in isolated pancreatic acinar cells.Scientific reports · 2025Article
- Clinical and CT/MRI imaging features of acute pancreatitis in older people.BMC geriatrics · 2025Article
- Admission hematocrit and fluctuating blood urea nitrogen levels predict the efficacy of blood purification treatment in severe acute pancreatitis patients.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025Article
- Combining bedside index of severity in acute pancreatitis (BISAP) and Charlson comorbidity index improves early risk stratification in biliary acute pancreatitis.Scientific reports · 2025Article
- Article
- Impact of Prediabetes on In-Hospital Mortality and Clinical Outcomes in Acute Pancreatitis: Insights from a Nationwide Inpatient Sample.Journal of clinical medicine · 2025Article
- Comorbidity burden and outcomes of endoscopic ultrasound-guided treatment of pancreatic fluid collections: Multicenter study with nationwide data-based validation.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2025Article
- Review
- Comparison of the effectiveness of different scoring systems and biochemical markers in determining the severity and complications of acute pancreatitis.Turkish journal of medical sciences · 2025Article
- Article
- Assessing Trends in Hospitalizations for Breast Cancer among Women in Korea: A Utilization of the Korea National Hospital Discharge In-depth Injury Survey (2006-2020).Journal of epidemiology and global health · 2024Article
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Authors and funding
10 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe impact of pre-existing comorbidities on acute pancreatitis (AP) mortality is not clearly defined. Our study aims to determine the trend in AP hospital mortality and the role of comorbidities as a predictor of hospital mortality.
methodsWe analyzed patients aged ≥ 18 years hospitalized with AP diagnosis between 2016 and 2019. The data have been extracted from the Spanish National Hospital Discharge Database of the Spanish Ministry of Health. We performed a univariate and multivariable analysis of the association of age, sex, and comorbidities with hospital mortality in patients with AP. The role of the Charlson and Elixhauser comorbidity indices as predictors of mortality was evaluated.
resultsA total of 110,021 patients diagnosed with AP were hospitalized during the analyzed period. Hospital mortality was 3.8%, with a progressive decrease observed in the years evaluated. In multivariable analysis, age ≥ 65 years (OR: 4.11, p < 0.001), heart disease (OR: 1.73, p < 0.001), renal disease (OR: 1.99, p < 0.001), moderate-severe liver disease (OR: 2.86, p < 0.001), peripheral vascular disease (OR: 1.43, p < 0.001), and cerebrovascular disease (OR: 1.63, p < 0.001) were independent risk factors for mortality. The Charlson > 1.5 (OR: 2.03, p < 0.001) and Elixhauser > 1.5 (OR: 2.71, p < 0.001) comorbidity indices were also independently associated with mortality, and ROC curve analysis showed that they are useful for predicting hospital mortality.
conclusionsAdvanced age, heart disease, renal disease, moderate-severe liver disease, peripheral vascular disease, and cerebrovascular disease before admission were independently associated with hospital mortality. The Charlson and Elixhauser comorbidity indices are useful for predicting hospital mortality in AP patients.
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