ArticleBiomedical optics express2023
Dysplasia and tumor discrimination in brain tissues by combined fluorescence, Raman, and diffuse reflectance spectroscopies.
Article in Biomedical optics express, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- High-sensitivity Raman spectroscopy for prostate cancer detection and tissue extraction guidance.Biomedical optics express · 2026Article
- Force-limited distance-measurable nerve root retractor plus intraoperative neurophysiological monitoring reduces L5 radiculitis in posterior lumbar interbody fusion.Journal of orthopaedic surgery and research · 2025Article
- Optical Methods for Brain Tumor Detection: A Systematic Review.Journal of clinical medicine · 2024Review
- Introduction to the Optics and the Brain 2023 feature issue.Biomedical optics express · 2024Article
- Optical Differentiation of Brain Tumors Based on Raman Spectroscopy and Cluster Analysis Methods.International journal of molecular sciences · 2023Article
Corrections and comments
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Authors and funding
7 authors.
Funding
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Abstract
Identification of neoplastic and dysplastic brain tissues is of paramount importance for improving the outcomes of neurosurgical procedures. This study explores the combined application of fluorescence, Raman and diffuse reflectance spectroscopies for the detection and classification of brain tumor and cortical dysplasia with a label-free modality. Multivariate analysis was performed to evaluate classification accuracies of these techniques-employed both in individual and multimodal configuration-obtaining high sensitivity and specificity. In particular, the proposed multimodal approach allowed discriminating tumor/dysplastic tissues against control tissue with 91%/86% sensitivity and 100%/100% specificity, respectively, whereas tumor from dysplastic tissues were discriminated with 89% sensitivity and 86% specificity. Hence, multimodal optical spectroscopy allows reliably differentiating these pathologies using a non-invasive, label-free approach that is faster than the gold standard technique and does not require any tissue processing, offering the potential for the clinical translation of the technology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.