Evidence map›Paper›PMID 36950379›Full record

ArticleCell genomics2023

The molecular consequences of androgen activity in the human breast.

Florian Raths, Mehran Karimzadeh, Nathan Ing, Andrew Martinez, Yoona Yang, Ying Qu, Tian-Yu Lee, Brianna Mulligan, Suzanne Devkota, Wayne T Tilley and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell genomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.

  1. Pooled it
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  8. [Application progress of single-cell RNA sequencing technology in breast development and related diseases].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
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  20. Androgen receptor in breast cancer and its clinical implication.Translational breast cancer research : a journal focusing on translational research in breast cancer · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 3 countries.

Florian RathsCenter for Bioinformatics and Functional Genomics, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Mehran KarimzadehDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.
Nathan IngCenter for Bioinformatics and Functional Genomics, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Andrew MartinezCenter for Bioinformatics and Functional Genomics, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Yoona YangCenter for Bioinformatics and Functional Genomics, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Ying QuDepartment of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Tian-Yu LeeDepartment of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Brianna MulliganCenter for Bioinformatics and Functional Genomics, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Suzanne DevkotaDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Wayne T TilleyDame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.
Theresa E HickeyDame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.
Bo WangVector Institute, Toronto, ON, Canada.
Armando E GiulianoDepartment of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Shikha BoseDepartment of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Hani GoodarziDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.
Edward C RayDepartment of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Xiaojiang CuiDepartment of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Simon R V KnottCenter for Bioinformatics and Functional Genomics, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Cedars-Sinai Medical Center · USVector Institute · CAFreemasons Foundation Centre for Men's Health · AUUniversity of Adelaide · AUUniversity of California, San Francisco · US

Funding

The Role of FOXCI in Basal-like Breast CancerR01CA151610 · NCI · SAINT JOHN'S CANCER INSTITUTE · PI CUI, XIAOJIANG · 2011 to 2022
$3.8M
An antisense RNA-mediated regulatory program that drives cancer metastasisR01CA240984 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GOODARZI, HANI · 2019 to 2023
$2.5M
The RNA structural code underlying pathological regulation of RNA splicing in metastasisR01CA244634 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GOODARZI, HANI · 2021 to 2025
$1.8M
Crosslinking-based targeted therapy for triple-negative breast cancerR21CA280458 · NCI · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI CHEN, SHENGXI, CUI, XIAOJIANG · 2023 to 2024
$418k
NCI NIH HHS R01 CA151610NCI NIH HHS R01 CA240984NCI NIH HHS R01 CA244634NCI NIH HHS R21 CA280458
6 · The paper itself

Abstract

Estrogen and progesterone have been extensively studied in the mammary gland, but the molecular effects of androgen remain largely unexplored. Transgender men are recorded as female at birth but identify as male and may undergo gender-affirming androgen therapy to align their physical characteristics and gender identity. Here we perform single-cell-resolution transcriptome, chromatin, and spatial profiling of breast tissues from transgender men following androgen therapy. We find canonical androgen receptor gene targets are upregulated in cells expressing the androgen receptor and that paracrine signaling likely drives sex-relevant androgenic effects in other cell types. We also observe involution of the epithelium and a spatial reconfiguration of immune, fibroblast, and vascular cells, and identify a gene regulatory network associated with androgen-induced fat loss. This work elucidates the molecular consequences of androgen activity in the human breast at single-cell resolution.

Indexed as

androgen regulation of human breast homeostasisbreast microenvironmentcellular metabolismchromatin regulationhormone receptorlactationmultiplexed immunohistochemistry by co-detection by indexingsingle-cell ATAC sequencingsingle-cell RNA sequencingtranscriptional control

Identifiers

PMID36950379
PMCPMC10025454
OpenAlexW4323543680

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.