Evidence map›Paper›PMID 36950675›Full record

ArticleAmerican journal of preventive cardiology2023

The association of sex-specific hormones with coronary artery plaque characteristics from Miami Heart (MiHeart) study.

Yaa A Kwapong, Garima Sharma, Javier Valero-Elizondo, Miguel Cainzos Achirica, Shozab S Ali, Michael J Blaha, Ron Blankstein, Michael D Shapiro, Lara Arias, Matthew J Budoff and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of preventive cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 1 country.

Yaa A KwapongJohns Hopkins Ciccarone Center for the Prevention of Cardiovascular Diseases, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Garima SharmaJohns Hopkins Ciccarone Center for the Prevention of Cardiovascular Diseases, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Javier Valero-ElizondoDivision of Cardiovascular Prevention and Wellness, Department of Cardiology, Houston Methodist DeBakey Heart & Vascular Center, Houston, TX, USA.
Miguel Cainzos AchiricaJohns Hopkins Ciccarone Center for the Prevention of Cardiovascular Diseases, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Shozab S AliMiami Cardiac and Vascular Institute, Baptist Health South Florida, Miami, FL, USA.
Michael J BlahaJohns Hopkins Ciccarone Center for the Prevention of Cardiovascular Diseases, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Ron BlanksteinBrigham and Women's Hospital Heart and Vascular Center, and Harvard Medical School, Boston, MA, USA.
Michael D ShapiroCenter for Prevention of Cardiovascular Disease, Section on Cardiovascular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Lara AriasCenter for Outcomes Research, Houston Methodist, Houston, TX, USA.
Matthew J BudoffDivision of Cardiology, Harbor UCLA Medical Center, Torrance, CA, USA.
Theodore FeldmanMiami Cardiac and Vascular Institute, Baptist Health South Florida, Miami, FL, USA.
Ricardo C CuryMiami Cardiac and Vascular Institute, Baptist Health South Florida, Miami, FL, USA.
Laxmi MehtaDivision of Cardiology, the Ohio State University School of Medicine, Columbus, OH, USA.
Jonathan FialkowMiami Cardiac and Vascular Institute, Baptist Health South Florida, Miami, FL, USA.
Khurram NasirJohns Hopkins Ciccarone Center for the Prevention of Cardiovascular Diseases, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Johns Hopkins University · USBaptist Health South Florida · USFlorida International University · USHouston Methodist · USHarbor–UCLA Medical Center · USHarvard University · USThe Ohio State University · USWake Forest University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The association of sex-specific hormones with coronary computed tomography angiography(CCTA)-based plaque characteristics in women without cardiovascular disease is not well understood. We investigated the association of sex-specific hormones with coronary artery plaque characteristics in a contemporary multiracial cohort with no clinical coronary artery disease (CAD). Methods: In this cross-sectional analysis, we utilized data from 2,325 individuals with no clinical CAD from the Miami Heart (MiHeart) study. Multivariable logistic regression models were used to investigate the association of sex hormones: sex hormone binding globulin (SHBG), dehydroepiandrosterone (DHEA), free and total testosterone, estradiol, with plaque characteristics among women and men. Results: Of the 1,155 women, 34.2% had any plaque and 3.4% had any high-risk plaque features (HRP) while among men ( Conclusion: Among young to middle-aged women with no clinical CAD, increasing estradiol and SHBG were associated with lower odds of any plaque and higher free testosterone was associated with HRP. Larger cohorts may be needed to validate this.

Indexed as

CAD, coronary artery diseaseCCTA, coronary computed tomography angiographyCoronary artery diseaseCT, computed tomographyCVD, cardiovascular diseaseDHEA, dehydroepiandrosteroneHRP, high-risk plaqueMiHeart, Miami heart studyPlaqueSex hormonesSHBG, sex hormone binding globulinTestosterone

Identifiers

PMID36950675
PMCPMC10025130
OpenAlexW4322774135

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.