ArticleFrontiers in endocrinology2023
Is there any association between early trimester Triglyceride-glucose index and incidence of hypertensive disorder of pregnancy and adverse pregnancy outcomes?
Article in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The correlation between triglyceride-glucose index in early pregnancy (<20 weeks) and pregnancy complications and adverse pregnancy outcomes: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Role of second-trimester hematological and biochemical indicators in predicting preeclampsia: a retrospective study.BMC pregnancy and childbirth · 2026Article
- Triglyceride glucose index and modified triglyceride glucose indices are instrumental to optimize 3P medical management for postpartum cardiovascular disease.The EPMA journal · 2026Article
- Association of late-pregnancy triglyceride-glucose index and growth differentiation factor 15 with adverse pregnancy outcomes in women with gestational diabetes mellitus.BMC pregnancy and childbirth · 2026Article
- Predictive Value of the second-Trimester Triglyceride-Glucose Index and Its Derived Indices for Macrosomia in Gestational Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Association between triglyceride-glucose index, placental inflammatory cytokines, and perinatal outcomes in preeclampsia.Frontiers in endocrinology · 2026Article
- Association between triglyceride glucose-body mass index and preeclampsia risk in advanced maternal age pregnant women-a retrospective cohort study.Scientific reports · 2025Article
- First-trimester atherogenic index of plasma and triglyceride-glucose indices in pregestational diabetes mellitus: associations with adverse pregnancy outcomes.BMC pregnancy and childbirth · 2025Article
- Impact of Blood Pressure Across the Life Course on Arterial Stiffness in Midlife: The Mediating Role of Metabolic Factors.MedComm · 2025Article
- Associations between triglyceride-glucose index in the early trimester of pregnancy and adverse pregnancy outcomes.BMC pregnancy and childbirth · 2025Article
- Uric acid to high-density lipoprotein cholesterol ratio is associated with the prevalence of diabetic kidney disease in euthyroid patients with type 1 diabetes mellitus in China: A multicenter cross-sectional study.Journal of diabetes investigation · 2025Article
- First-trimester triglyceride-glucose index and birth weight: a retrospective cohort mediation analysis of preterm birth and gestational complications.BMC pregnancy and childbirth · 2025Article
- Association between triglyceride-glucose index and hypertension in adults with cancer from NHANES 2005-2018: a cross-sectional study.BMC cancer · 2025Article
- Dynamic Lipid-Glycaemic Index and Inflammation-Endothelial Shifts and Fetal Aortic Wall Thickening: A Repeated-Measures Gestational Phenotyping Study.Medicina (Kaunas, Lithuania) · 2025Article
- Association of the Triglyceride-Glucose Index During the First Trimester of Pregnancy with Adverse Perinatal Outcomes.Diagnostics (Basel, Switzerland) · 2025Article
- Association between triglyceride-glucose index in early pregnancy and risk of preeclampsia: a multicenter retrospective cohort study.Lipids in health and disease · 2025Article
- The first-trimester triglyceride glucose-body mass index is a valuable predictor for adverse pregnancy outcomes.BMC pregnancy and childbirth · 2025Article
- Second-trimester triglyceride-glucose index to predict adverse outcomes in women with gestational diabetes mellitus: A retrospective multicenter cohort study.Journal of diabetes investigation · 2024Article
- Triglyceride-glucose index: A promising biomarker for predicting risks of adverse pregnancy outcomes in Hangzhou, China.Preventive medicine reports · 2024Article
- Positive association of triglyceride glucose index and gestational diabetes mellitus: a retrospective cohort study.Frontiers in endocrinology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Insulin resistance (IR) is a normal feature of pregnancy and plays a crucial role in the pathophysiology of hypertensive disorder of pregnancy (HDP). The triglyceride-glucose index (TyG index) has been shown as a simple and reliable alternative IR marker. This work aimed to investigate the association between the TyG index and the incidence of HDP and adverse pregnancy outcomes. Methods: From January 2016 to December 2018, 289 women with HDP and 861 women without HDP were recruited at Shanghai Fifth People's Hospital, Fudan University to determine the relationship between the TyG index and the incidence of HDP and adverse pregnancy outcomes. Results: In the case-control study, the incidence of HDP was found to be significantly associated with the TyG index. Moreover, logistic regression indicated that the TyG index is an independent risk factor for HDP development and incidence of low birth weight (LBW) and fetal distress. In the cohort study, the results showed that the TyG index increased, there was a stepwise increase in HDP incidence, SBP, and DBP levels one week before delivery as well as in LBW and fetal distress incidence. The early trimester TyG index was positively associated with pre-pregnancy BMI, systolic blood pressure (SBP), and diastolic blood pressure (DBP) one week before delivery. Spline regression showed that there was a significant linear association between HDP incidence and early trimester TyG index when it was >8.5. Conclusions: This work suggested that the early trimester TyG index was closely associated with the development of HDP and adverse pregnancy outcomes.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.