Evidence map›Paper›PMID 36950689›Full record

ReviewFrontiers in endocrinology2023

Understanding the relationships between physiological and psychosocial stress, cortisol and cognition.

Katharine Ann James, Juliet Ilena Stromin, Nina Steenkamp, Marc Irwin Combrinck

Registry-linked trialFull text readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07732036 (The Effectiveness and Acceptability of Inhalation Aromatherapy for Patients Undergoing Conservative Sharp Wound Debridement), which is not on this map. Cited by 152 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
152citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07732036 narecruitingnot on this mapstarted 2026, after this paper: background citation

The Effectiveness and Acceptability of Inhalation Aromatherapy for Patients Undergoing Conservative Sharp Wound Debridement: A Pilot Randomized Controlled Trial

TypeinterventionalSponsorSingapore General HospitalRan2026 to 2028Enrolled40ConditionsAromatherapyArmsInhalation Aromatherapy
3 · Its place in the literature

Who cites it

152 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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  16. Article
  17. Adverse life events and cognition in older adults: the role of gender and psychological resilience.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026
    Article
  18. Article
  19. Review
  20. Mechanistic signatures of comorbid PTSD with cognitive impairment implicate cortisol-induced neural toxicity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article

92 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Katharine Ann JamesApplied Cognitive Science and Experimental Neuropsychology Team (ACSENT) Laboratory, Department of Psychology, University of Cape Town, Cape Town, South Africa.
Juliet Ilena StrominApplied Cognitive Science and Experimental Neuropsychology Team (ACSENT) Laboratory, Department of Psychology, University of Cape Town, Cape Town, South Africa.
Nina SteenkampApplied Cognitive Science and Experimental Neuropsychology Team (ACSENT) Laboratory, Department of Psychology, University of Cape Town, Cape Town, South Africa.
Marc Irwin CombrinckDivision of Geriatric Medicine, Department of Medicine, University of Cape Town, Cape Town, South Africa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stress is viewed as a state of real or perceived threat to homeostasis, the management of which involves the endocrine, nervous, and immune systems. These systems work independently and interactively as part of the stress response. The scientific stress literature, which spans both animal and human studies, contains heterogeneous findings about the effects of stress on the brain and the body. This review seeks to summarise and integrate literature on the relationships between these systems, examining particularly the roles of physiological and psychosocial stress, the stress hormone cortisol, as controlled by the hypothalamic-pituitary-adrenal (HPA) axis, and the effects of stress on cognitive functioning. Health conditions related to impaired HPA axis functioning and their associated neuropsychiatric symptoms will also be considered. Lastly, this review will provide suggestions of clinical applicability for endocrinologists who are uniquely placed to measure outcomes related to endocrine, nervous and immune system functioning and identify areas of intervention.

Indexed as

CognitionHydrocortisoneStress, PsychologicalAnimalsHumansHypothalamo-Hypophyseal SystemPituitary-Adrenal SystemHydrocortisonecognitioncortisolendocrinologistglucocorticoidshypothalamic - pituitary - adrenal axismental healthphysiological stresspsychosocial stress

Identifiers

PMID36950689
PMCPMC10025564

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read17
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.