Evidence map›Paper›PMID 36958267›Full record

ArticleEuropean journal of medicinal chemistry2023

Investigation of the effect of structure modification of furamidine on the DNA minor groove binding and antiprotozoal activity.

Abdelbasset A Farahat, Arvind Kumar, Tanja Wenzler, Reto Brun, Ananya Paul, Pu Guo, W David Wilson, David W Boykin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. NewRSC medicinal chemistry · 2025
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Abdelbasset A FarahatMasters of Pharmaceutical Sciences Program, California Northstate University, Elk Grove, CA, 95757, USA; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. Electronic address: abdelbasset.farahat@cnsu.edu.
Arvind KumarDepartment of Chemistry, Georgia State University, Atlanta, GA, 30303, USA.
Tanja WenzlerSwiss Tropical and Public Health Institute, Basel, 4002, Switzerland; University of Basel, Basel, 4003, Switzerland.
Reto BrunSwiss Tropical and Public Health Institute, Basel, 4002, Switzerland; University of Basel, Basel, 4003, Switzerland.
Ananya PaulDepartment of Chemistry, Georgia State University, Atlanta, GA, 30303, USA.
Pu GuoDepartment of Chemistry, Georgia State University, Atlanta, GA, 30303, USA.
W David WilsonDepartment of Chemistry, Georgia State University, Atlanta, GA, 30303, USA.
David W BoykinDepartment of Chemistry, Georgia State University, Atlanta, GA, 30303, USA.

Funding

Molecular Design for Specific Recognition of Functional DNA SequencesR01GM111749 · NIGMS · GEORGIA STATE UNIVERSITY · PI WILSON, W DAVID · 2014 to 2021
$2.5M
NIGMS NIH HHS R01 GM111749
6 · The paper itself

Abstract

New analogs of the antiprotozoal agent Furamidine were prepared utilizing Stille coupling reactions and amidation of the bisnitrile intermediate using lithium bis-trimethylsilylamide. Both the phenyl groups and the furan moiety of furamidine were replaced by heterocycles including thiophene, selenophene, indole or benzimidazole. Based upon the ΔTm and the CD results, the new compounds showed strong binding to the DNA minor groove. The new analogues are also more active both in vitro and in vivo than furamidine. Compounds 7a, 7b, and 7f showed the highest activity in vivo by curing 75% of animals, and this merits further evaluation.

Indexed as

Antiprotozoal AgentsBenzamidinesAnimalsDNAAntiprotozoal AgentsBenzamidinesDNAfuramidineAmidinesAntimalarialAntitrypanosomalDNA minor Groove bindersLithium bis(trimethylsilyl)amideStille coupling

Identifiers

PMID36958267
PMCPMC10127280

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.