ArticleThe European respiratory journal2023
Cardiopulmonary exercise testing during follow-up after acute pulmonary embolism.
Article in The European respiratory journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Chronic thromboembolism phenotypes after acute pulmonary embolism: identification with the SEARCH algorithm.The European respiratory journal · 2026Observational
- Post-pulmonary embolism cardiac impairment and chronic thromboembolic pulmonary hypertension after ultrasound-assisted catheter-directed thrombolysis for acute pulmonary embolism.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Functional recovery after pulmonary embolism: A pilot study using metabolic monitoring during the 6-minute walk test.Respiratory medicine · 2026Observational
- Post-Pulmonary Embolism Syndrome: New Phenotypes Come into Focus.Journal of clinical medicine · 2026Review
- Key elements of follow-up care after acute pulmonary embolism focusing on long-term sequelae: a Delphi study among European experts.European heart journal. Quality of care & clinical outcomes · 2025Article
- Cardiopulmonary Exercise Testing in People With Dyspnea With a Recent Acute Pulmonary Embolism.CHEST pulmonary · 2025Article
- Coronary artery stenosis associated with right ventricular dysfunction in acute pulmonary embolism: A case-control study.Chinese medical journal · 2025Article
- Advancing Cardiovascular Risk Stratification and Functional Assessment: A Narrative Review of CPET and ESE Applications.Healthcare (Basel, Switzerland) · 2025Review
- Estimated annual healthcare costs after acute pulmonary embolism: results from a prospective multicentre cohort study.European heart journal. Quality of care & clinical outcomes · 2025Article
- Exercise Capacity Following Pulmonary Embolism in Children and Adolescents.CHEST pulmonary · 2025Article
- Do Hemodynamic Definitions of Chronic Thromboembolic Pulmonary Hypertension Distinguish between Distinct Phenotypes of Chronic Thromboembolic Pulmonary Disease?Annals of the American Thoracic Society · 2025Article
- Healthcare resource utilisation and associated costs after low-risk pulmonary embolism: pre-specified analysis of the Home Treatment of Pulmonary Embolism (HoT-PE) study.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Cardiopulmonary Exercise Testing With Simultaneous Echocardiography After Pulmonary Embolism.Pulmonary circulation · 2025Article
- Chronic Thromboembolic Pulmonary Hypertension Incidence, Post-pulmonary Embolism Syndrome and Possible Role of Transcatheter Therapy in Prevention.Interventional cardiology (London, England) · 2025Review
- The Functional Characterization of Venous Thromboembolic Disease (FUVID) study: rationale, design, and methods of a prospective, observational, multicenter study to evaluate mechanisms of exercise intolerance and dyspnea following pediatric pulmonary embolism.Research and practice in thrombosis and haemostasis · 2025Article
- Cardiopulmonary exercise testing following acute pulmonary embolism: Systematic review and pooled analysis of global studies.Pulmonary circulation · 2024Article
- Electronically delivered rehabilitation after acute pulmonary embolism is safe and improves quality of life.The European respiratory journal · 2024Article
- Association between Mid-Term Functionality and Clinical Severity in Patients Hospitalized for Pulmonary Embolism.Healthcare (Basel, Switzerland) · 2024Article
- Functional limitations 3 and 12 months after venous thromboembolism: a cohort study.Research and practice in thrombosis and haemostasis · 2024Article
- Cardiopulmonary exercise test to detect cardiac dysfunction from pulmonary vascular disease.Respiratory research · 2024Review
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCardiopulmonary exercise testing (CPET) may provide prognostically valuable information during follow-up after pulmonary embolism (PE). Our objective was to investigate the association of patterns and degree of exercise limitation, as assessed by CPET, with clinical, echocardiographic and laboratory abnormalities and quality of life (QoL) after PE.
methodsIn a prospective cohort study of unselected consecutive all-comers with PE, survivors of the index acute event underwent 3- and 12-month follow-ups, including CPET. We defined cardiopulmonary limitation as ventilatory inefficiency or insufficient cardiocirculatory reserve. Deconditioning was defined as peak O
resultsOverall, 396 patients were included. At 3 months, prevalence of cardiopulmonary limitation and deconditioning was 50.1% (34.7% mild/moderate; 15.4% severe) and 12.1%, respectively; at 12 months, it was 44.8% (29.1% mild/moderate; 15.7% severe) and 14.9%, respectively. Cardiopulmonary limitation and its severity were associated with age (OR per decade 2.05, 95% CI 1.65-2.55), history of chronic lung disease (OR 2.72, 95% CI 1.06-6.97), smoking (OR 5.87, 95% CI 2.44-14.15) and intermediate- or high-risk acute PE (OR 4.36, 95% CI 1.92-9.94). Severe cardiopulmonary limitation at 3 months was associated with the prospectively defined, combined clinical-haemodynamic end-point of "post-PE impairment" (OR 6.40, 95% CI 2.35-18.45) and with poor disease-specific and generic health-related QoL.
conclusionsAbnormal exercise capacity of cardiopulmonary origin is frequent after PE, being associated with clinical and haemodynamic impairment as well as long-term QoL reduction. CPET can be considered for selected patients with persisting symptoms after acute PE to identify candidates for closer follow-up and possible therapeutic interventions.
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