Evidence map›Paper›PMID 36960914›Full record

ArticleAnnals of the New York Academy of Sciences2023

Immunometabolism at the crossroads of obesity and cancer-a Keystone Symposia report.

Jennifer Cable, Jeffrey C Rathmell, Erika L Pearce, Ping-Chih Ho, Marcia C Haigis, Murad R Mamedov, Meng-Ju Wu, Susan M Kaech, Lydia Lynch, Mark A Febbraio and 19 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of the New York Academy of Sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 20 institutions in 12 countries.

Jennifer CablePhD Science Writer, New York, New York, USA.
Jeffrey C RathmellVanderbilt-Ingram Cancer Center; Vanderbilt Center for Immunobiology; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Erika L PearceBloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, Maryland, USA.
Ping-Chih HoDepartment of Fundamental Oncology and Ludwig Institute for Cancer Research, University of Lausanne, Lausanne, Switzerland.
Marcia C HaigisDepartment of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, USA.
Murad R MamedovGladstone-UCSF Institute of Genomic Immunology and Department of Medicine, University of California San Francisco, San Francisco, California, USA.
Meng-Ju WuCancer Center, Massachusetts General Hospital; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Susan M KaechNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, California, USA.
Lydia LynchBrigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Mark A FebbraioMonash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Sagar P BapatDiabetes Center and Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA.
Hanna S HongDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA.
Weiping ZouDepartment of Surgery; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center; Department of Pathology; Graduate Program in Immunology; Graduate Program in Cancer Biology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA.
Yasmine BelkaidMetaorganism Immunity Section, Laboratory of Immune System Biology, and NIAID Microbiome Program National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Zuri A SullivanDepartment of Immunobiology, Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA.
Andrea KellerDepartment of Biological Chemistry and Pharmacology, College of Medicine; and Comprehensive Cancer Center, Wexner Medical Center, Arthur G. James Cancer Hospital, The Ohio State University, Columbus, Ohio, USA.
Stefanie K WculekCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Douglas R GreenSt. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Catherine PosticUniversité Paris Cité, CNRS, INSERM, Institut Cochin, Paris, France.
Ido AmitDepartment of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel.
Salvador Aznar BenitahInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST) and Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain.
Russell G JonesDepartment of Metabolism and Nutritional Programming, Van Andel Research Institute, Grand Rapids, Michigan, USA.
Miguel Reina-CamposUniversity of California, San Diego, La Jolla, California, USA.
Santiago Valle TorresDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.
Semir BeyazCold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.
Donal BrennanUCD Gynecological Oncology Group, UCD School of Medicine, Catherine McAuley Research Centre, Mater Misericordiae University Hospital, Belfield, Ireland.
Luke A J O'NeillSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland.
Rachel J PerryDepartment of Cellular and Molecular Physiology and Department of Internal Medicine (Endocrinology), Yale University School of Medicine, New Haven, Connecticut, USA.
Dirk BrennerExperimental and Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Harvard University · USCold Spring Harbor Laboratory · USGladstone Institutes · USHarvard Stem Cell Institute · USInstitute for Research in Biomedicine · ESInstitute of Immunology · HRMater Misericordiae University Hospital · IEMonash University · AUNational Institutes of Health · USPeter Doherty Institute · AUSalk Institute for Biological Studies · USSidney Kimmel Cancer Center · USSpanish National Centre for Cardiovascular Research · ESSt. Jude Children's Research Hospital · USThe Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute · USTrinity College · CAUniversité Paris Cité · FRUniversity of California, San Diego · USUniversity of California, San Francisco · USUniversity of Lausanne · CH

Funding

Single-Cell Biology Shared ResourceP30CA045508 · COLD SPRING HARBOR LABORATORY · 1987 to 2025
$27.2M
Yale Clinical and Translational Science AwardUL1TR001863 · YALE UNIVERSITY · 2025 to 2025
$9.9M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007198 · UNIVERSITY OF CALIFORNIA SAN DIEGO · 1985 to 2005
$5.4M
Role of nutrition in the Control of ImmunityZIAAI001133 · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2025 to 2025
$71k
NCATS NIH HHS UL1 TR001863NCI NIH HHS P30 CA045508NHLBI NIH HHS K38 HL154202NHLBI NIH HHS R38 HL143581NIDDK NIH HHS F30 DK096828NIGMS NIH HHS T32 GM007198
6 · The paper itself

Abstract

Immunometabolism considers the relationship between metabolism and immunity. Typically, researchers focus on either the metabolic pathways within immune cells that affect their function or the impact of immune cells on systemic metabolism. A more holistic approach that considers both these viewpoints is needed. On September 5-8, 2022, experts in the field of immunometabolism met for the Keystone symposium "Immunometabolism at the Crossroads of Obesity and Cancer" to present recent research across the field of immunometabolism, with the setting of obesity and cancer as an ideal example of the complex interplay between metabolism, immunity, and cancer. Speakers highlighted new insights on the metabolic links between tumor cells and immune cells, with a focus on leveraging unique metabolic vulnerabilities of different cell types in the tumor microenvironment as therapeutic targets and demonstrated the effects of diet, the microbiome, and obesity on immune system function and cancer pathogenesis and therapy. Finally, speakers presented new technologies to interrogate the immune system and uncover novel metabolic pathways important for immunity.

Indexed as

NeoplasmsHumansImmune SystemMetabolic Networks and PathwaysObesityTumor Microenvironmentcancerimmunityimmunometabolismimmunotherapymetabolismobesity

Identifiers

PMID36960914
PMCPMC10367315
OpenAlexW4360805545

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.