Evidence map›Paper›PMID 36964443›Full record

ArticleHormones (Athens, Greece)2023

Unraveling the role of resistin, retinol-binding protein 4 and adiponectin produced by epicardial adipose tissue in cardiac structure and function: evidence of a paracrine effect.

Georgios A Christou, Christina E Andriopoulou, Alexandra Liakopoulou, Eirini Tsape, Efstratios Apostolakis, Alexandros D Tselepis, Maria Konstandi, Gema Frühbeck, Dimitrios N Kiortsis

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hormones (Athens, Greece), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Observational
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Georgios A ChristouAtherothrombosis Research Centre, Medical School, University of Ioannina, 45110, Ioannina, Greece.
Christina E AndriopoulouDepartment of Pharmacology, Medical School, University of Ioannina, Ioannina, Greece.
Alexandra LiakopoulouDepartment of Cardiac Surgery, University Hospital of Ioannina, Ioannina, Greece.
Eirini TsapeAtherothrombosis Research Centre, Medical School, University of Ioannina, 45110, Ioannina, Greece.
Efstratios ApostolakisDepartment of Cardiac Surgery, University Hospital of Ioannina, Ioannina, Greece.
Alexandros D TselepisAtherothrombosis Research Centre/Laboratory of Biochemistry, Department of Chemistry, University of Ioannina, Ioannina, Greece.
Maria KonstandiDepartment of Pharmacology, Medical School, University of Ioannina, Ioannina, Greece.
Gema FrühbeckDepartment of Endocrinology and Nutrition, Clínica Universidad de Navarra, Pamplona, Spain.
Dimitrios N KiortsisAtherothrombosis Research Centre, Medical School, University of Ioannina, 45110, Ioannina, Greece. dkiorts@uoi.gr.ORCID http://orcid.org/0000-0002-2082-3747
University of Ioannina · GRUniversity Hospital of Ioannina · GRClinica Universidad de Navarra · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAdipokines produced by adipose tissue have been found to be involved in the pathophysiology of metabolic and cardiovascular diseases. We aimed to investigate the relationships of resistin, retinol-binding protein 4 (RBP4) and adiponectin produced by epicardial adipose tissue with coronary artery disease (CAD) and cardiac structure and function.

methodsForty-one non-diabetic males scheduled for cardiothoracic surgery were examined. Anthropometric measurements, echocardiography, coronary angiography, and blood analysis were performed preoperatively. We measured the serum levels of resistin, RBP4, and adiponectin and their mRNA expression in thoracic subcutaneous adipose tissue and two epicardial adipose tissue samples, one close to left anterior descending artery (LAD) (resistin-LAD, RBP4-LAD, adiponectin-LAD), and another close to the right coronary artery (RCA) (resistin-RCA, RBP4-RCA, adiponectin-RCA).

resultsLeft ventricular (LV) ejection fraction correlated negatively with adiponectin-LAD (rho =  - 0.390, p = 0.025). The ratio of early to late diastolic transmitral flow velocity, as an index of LV diastolic function, correlated negatively with resistin-LAD (rho =  - 0.529, p = 0.024) and RBP4-LAD (rho =  - 0.458, p = 0.049). There was no difference in epicardial adipose tissue mRNA expression of resistin, RBP4, and adiponectin between individuals with CAD and those without CAD. When we compared the individuals with CAD in the LAD with those without CAD in the LAD, there was no difference in resistin-LAD, RBP4-LAD, and adiponectin-LAD. There was no difference in resistin-RCA, RBP4-RCA, and adiponectin-RCA between the individuals with CAD in the RCA and those without CAD in the RCA.

conclusionElevation of epicardial adipose tissue mRNA expression of adiponectin was associated with LV systolic dysfunction, while that of both resistin and RBP4 was linked to LV diastolic dysfunction.

Indexed as

AdiponectinCoronary Artery DiseaseAdipose TissueHumansMaleResistinRetinol-Binding ProteinsRetinol-Binding Proteins, PlasmaRNA, MessengerAdiponectinRBP4 protein, humanResistinRetinol-Binding ProteinsRetinol-Binding Proteins, PlasmaRNA, MessengerAdipokinesAdipose tissueCoronary artery diseaseEpicardial fatLeft ventricular function

Identifiers

PMID36964443
PMCPMC10209261
OpenAlexW4360827133

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.