Evidence map›Paper›PMID 36964583›Full record

ArticleTrials2023

The integration of rapid qualitative research in clinical trials: reflections from the ward-based goal-directed fluid therapy (GDFT) in acute pancreatitis feasibility trial.

Cecilia Vindrola-Padros, Farid Froghi, Vignesh Gopalan, Sachan Maruthan, Helder Filipe, Margaret McNeil, Sara Mingo Garcia, Brian Davidson, GAP trial team

Full text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. [European journal of nuclear medicine and molecular imaging · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cecilia Vindrola-PadrosDepartment of Targeted Intervention, University College London, 3Rd Floor Charles Bell House, 43-45 Foley Street, London, W1W 7TY, UK. c.vindrola@ucl.ac.uk.ORCID http://orcid.org/0000-0001-7859-1646
Farid FroghiDivision of Surgery & Interventional Sciences, University College London, London, UK.
Vignesh GopalanRoyal Free London NHS Foundation Trust, London, UK.
Sachan MaruthanRoyal Free London NHS Foundation Trust, London, UK.
Helder FilipeRoyal Free London NHS Foundation Trust, London, UK.
Margaret McNeilRoyal Free London NHS Foundation Trust, London, UK.
Sara Mingo GarciaRoyal Free London NHS Foundation Trust, London, UK.
Brian DavidsonDivision of Surgery & Interventional Sciences, University College London, London, UK.
GAP trial team

Funding

Research for Patient Benefit Programme PB-PG-0815-20002
6 · The paper itself

Abstract

backgroundThere has been an increase in the integration of qualitative studies in randomised controlled trials. The purpose of this article is to reflect on our experience of carrying out a rapid qualitative study during a feasibility trial of goal-directed fluid therapy (GDFT) in patients with acute pancreatitis, including our sharing of emerging findings and the use of these findings by the trial team.

methodsThe study was designed as a rapid feedback evaluation and combined interviews with staff and patients who took part in the trial.

findingsThe rapid qualitative study pointed to common problems in trial recruitment among multiple sites, where lack of engagement of clinical teams across sites might impact negatively on patient recruitment. The article describes how the use of rapid feedback loops can be used as the trial is ongoing to inform changes in implementation. It also covers the potential challenges of working rapidly and collaborative with the trial team.

conclusionsRapid feedback evaluations can be used to generate findings across all stages of trial design and delivery. Additional research is required to explore the implementation of this research design in other settings and trial designs.

Indexed as

PancreatitisAcute DiseaseFeasibility StudiesFluid TherapyGoalsHumansQualitative ResearchAcute pancreatitisClinical trialsFeedback loopsRapid qualitative research

Identifiers

PMID36964583
PMCPMC10039605

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read2
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.