Evidence map›Paper›PMID 36967853›Full record

ReviewPostepy w kardiologii interwencyjnej = Advances in interventional cardiology2022

Hybrid techniques for myocardial regeneration: state of the art and future perspectives.

Anna Kędziora, Janusz Konstanty-Kalandyk, Radosław Litwinowicz, Piotr Mazur, Bogusław Kapelak, Jacek Piątek

Open access · goldAbstract readReview
In one paragraph

Review in Postepy w kardiologii interwencyjnej = Advances in interventional cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Left main coronary artery disease treated with beating heart surgery: 10-year single center results.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2024
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 3 countries.

Anna KędzioraDepartment of Cardiovascular Surgery and Transplantology, John Paul II Hospital, Krakow, Poland.
Janusz Konstanty-KalandykDepartment of Cardiovascular Surgery and Transplantology, John Paul II Hospital, Krakow, Poland.
Radosław LitwinowiczJagiellonian University Medical College, Krakow, Poland.
Piotr MazurDepartment of Cardiovascular Surgery and Transplantology, John Paul II Hospital, Krakow, Poland.
Bogusław KapelakDepartment of Cardiovascular Surgery and Transplantology, John Paul II Hospital, Krakow, Poland.
Jacek PiątekDepartment of Cardiovascular Surgery and Transplantology, John Paul II Hospital, Krakow, Poland.
Jagiellonian University · PLJohn Paul II Hospital · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myocardium has a limited proliferative capacity, and adult hearts are considered incapable of regenerating after injury. A significant loss in the viable myocardium eventually diminishes the heart's ability to contract synchronously, leading to heart failure. Despite the development in interventional and pharmacological treatment for ischemic heart disease and heart failure, there is a significant number of highly symptomatic patients. For these individuals, treatments that stimulate myocardial regeneration can offer alleviation of dyspnea and angina and improvement in quality of life. Stem cells are known to promote neovascularization and endothelial repair. Various stem cell lines have been investigated over the years to establish those with the highest potential to differentiate into cardiomyocytes, including bone marrow-derived mononuclear cells, mesenchymal stromal cells, CD34+, CD133+, endothelial progenitor cells, and adipose-derived mesenchymal stromal cells. Stem cell studies were based on several delivery pathways: infusion into coronary vessels, direct injection into the injured region of the myocardium, and delivery within the novel bioengineered scaffolds. Acellular materials have also been investigated over the years. They demonstrate the therapeutic potential to promote angiogenesis and release of growth factors to improve the restoration of critical components of the extracellular matrix. This review summarizes hybrid cardiac regeneration treatments that combine novel bioengineering techniques with delivery approaches that cardiac surgeons can provide.

Indexed as

bioprintingcardiac regenerationcardiac surgeryhybrid techniquescaffoldstem cells

Identifiers

PMID36967853
PMCPMC10031663
OpenAlexW4312383704

What Socratic holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.