Evidence map›Paper›PMID 36968274›Full record

ReviewFrontiers in molecular biosciences2023

Using mass spectrometry imaging to visualize age-related subcellular disruption.

Kelly A Hogan, Julianna D Zeidler, Heather K Beasley, Abrar I Alsaadi, Abdulkareem A Alshaheeb, Yi-Chin Chang, Hua Tian, Antentor O Hinton, Melanie R McReynolds

Open access · goldFull text readReview
In one paragraph

Review in Frontiers in molecular biosciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Mitochondria in disease: changes in shapes and dynamics.Trends in biochemical sciences · 2024
    Review
  7. Spatial pharmacology using mass spectrometry imaging.Trends in pharmacological sciences · 2024
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Kelly A HoganDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, United States.
Julianna D ZeidlerInstituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Heather K BeasleyDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, United States.
Abrar I AlsaadiDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, United States.
Abdulkareem A AlshaheebDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, United States.
Yi-Chin ChangDepartment of Chemistry, Pennsylvania State University, University Park, PA, United States.
Hua TianHuck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA, United States.
Antentor O HintonDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, United States.
Melanie R McReynoldsDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, United States.
Pennsylvania State University · USVanderbilt University · USUniversidade Federal do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolic homeostasis balances the production and consumption of energetic molecules to maintain active, healthy cells. Cellular stress, which disrupts metabolism and leads to the loss of cellular homeostasis, is important in age-related diseases. We focus here on the role of organelle dysfunction in age-related diseases, including the roles of energy deficiencies, mitochondrial dysfunction, endoplasmic reticulum (ER) stress, changes in metabolic flux in aging (e.g., Ca

Indexed as

agingGolgi complexmass spec imagingMERCsmetabolic fluxmitocchondrial dysfunctionspatial omics

Identifiers

PMID36968274
PMCPMC10032471
OpenAlexW4323567355

What Socratic holds

Textfull text, public
LicenceCC BY
reference markers read5
measurements read12
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.