Evidence map›Paper›PMID 36969608›Full record

ArticleFrontiers in physiology2023

Identification of hypertrophy-modulating Cullin-RING ubiquitin ligases in primary cardiomyocytes.

Maximillian Fischer, Moritz Jakab, Marc N Hirt, Tessa R Werner, Stefan Engelhardt, Antonio Sarikas

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Maximillian FischerInstitute of Pharmacology and Toxicology, Technische Universität München, Munich, Germany.
Moritz JakabInstitute of Pharmacology and Toxicology, Technische Universität München, Munich, Germany.
Marc N HirtInstitute of Pharmacology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Tessa R WernerInstitute of Pharmacology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Stefan EngelhardtInstitute of Pharmacology and Toxicology, Technische Universität München, Munich, Germany.
Antonio SarikasInstitute of Pharmacology and Toxicology, Paracelsus Medical University, Salzburg, Austria.
German Centre for Cardiovascular Research · DEParacelsus Medical University · ATTechnical University of Munich · DEUniversität Hamburg · DEUniversity Medical Center Hamburg-Eppendorf · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cullin-RING ubiquitin ligases (CRL) regulate numerous biological processes in the heart and have been implicated in regulating cardiac hypertrophy. This study aimed to identify novel hypertrophy-modulating CRLs in cardiomyocytes (CM). A functional genomic approach using siRNA-mediated depletion and automated microscopy was employed to screen for cell size-modulating CRLs in neonatal rat CM. Screening hits were confirmed by

Indexed as

cardiomyocyteCullin-RING E3 ligase (CRL)F-box proteinFbxo25hypertrophyphenotypic screen

Identifiers

PMID36969608
PMCPMC10030680
OpenAlexW4323567133

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read48
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.