Evidence map›Paper›PMID 36969694›Full record

ArticleMaterials today. Bio2023

A photoactive injectable antibacterial hydrogel to support chemo-immunotherapeutic effect of antigenic cell membrane and sorafenib by near-infrared light mediated tumor ablation.

Samin Abbaszadeh, Mohammad Reza Eskandari, Vahideh Nosrati-Siahmazgi, Kiyan Musaie, Soraya Mehrabi, Ruikang Tang, Mohammad Reza Jafari, Bo Xiao, Vahid Hosseinpour Sarmadi, Fakhri Haghi and 4 more

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 4 countries.

Samin AbbaszadehDepartment of Pharmacology, School of Medicine, Zanjan University of Medical Sciences, 45139-56111, Zanjan, Iran.
Mohammad Reza EskandariDepartment of Pharmacology and Toxicology, School of Pharmacy, Zanjan University of Medical Science, 45139-56184, Zanjan, Iran.
Vahideh Nosrati-SiahmazgiDepartment of Pharmaceutical Biomaterials, School of Pharmacy, Zanjan University of Medical Science, 45139-56184, Zanjan, Iran.
Kiyan MusaieDepartment of Pharmaceutical Biomaterials, School of Pharmacy, Zanjan University of Medical Science, 45139-56184, Zanjan, Iran.
Soraya MehrabiDepartment of Neuroscience, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, 14496-14535, Tehran, Iran.
Ruikang TangCenter for Biomaterials and Biopathways, Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang, 310027, China.
Mohammad Reza JafariDepartment of Pharmacology, School of Medicine, Zanjan University of Medical Sciences, 45139-56111, Zanjan, Iran.
Bo XiaoState Key Laboratory of Silkworm Genome Biology, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing, 400715, China.
Vahid Hosseinpour SarmadiCellular and Molecular Research Center, Iran University of Medical Sciences, 14496-14535, Tehran, Iran.
Fakhri HaghiDepartment of Microbiology and Immunology, School of Medicine, Zanjan University of Medical Sciences, 45139-56111, Zanjan, Iran.
Bo Zhi ChenBeijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, China.
Xin Dong GuoBeijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, China.
Hélder A SantosDepartment of Biomedical Engineering, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, Netherlands.
Mohammad-Ali ShahbaziDepartment of Biomedical Engineering, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, Netherlands.
Zanjan University of Medical Sciences · IRBeijing University of Chemical Technology · CNIran University of Medical Sciences · IRUniversity Medical Center Groningen · NLSouthwest University · CNUniversity of Zanjan · IRZhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intravenously administered nanocarriers suffer from off-target distribution, pre-targeting drug leakage, and rapid clearance, limiting their efficiency in tumor eradication. To bypass these challenges, an injectable hydrogel with time- and temperature-dependent viscosity enhancement behavior and self-healing property are reported to assist in the retention of the hydrogel in the tumor site after injection. The cancer cell membrane (CCM) and sorafenib are embedded into the hydrogel to elicit local tumor-specific immune responses and induce cancer cell apoptosis, respectively. In addition, hyaluronic acid (HA) coated Bi

Indexed as

Breast cancerChemotherapyCombination therapyImmunotherapyPhotothermal therapy

Identifiers

PMID36969694
PMCPMC10034508
OpenAlexW4324144183

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read45
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.