Evidence map›Paper›PMID 36969825›Full record

ArticleFrontiers in nutrition2023

Can plasma vitamin C predict survival in stage IV colorectal cancer patients? Results of a prospective cohort study.

Sally Temraz, Jana Jabbour, Farah Nassar, Remie El Helou, Ruba Hadla, Maria Mezher, Ahmed El Lakkiss, Maya Charafeddine, Rihab Nasr, Ali Shamseddine

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Sally TemrazDepartment of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
Jana JabbourNutrition Program, Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, Beirut, Lebanon.
Farah NassarDepartment of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
Remie El HelouDepartment of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
Ruba HadlaDepartment of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
Maria MezherDepartment of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
Ahmed El LakkissDepartment of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
Maya CharafeddineDepartment of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
Rihab NasrDepartment of Anatomy, Cell Biology and Physiology, American University of Beirut Medical Center, Beirut, Lebanon.
Ali ShamseddineDepartment of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
American University of Beirut Medical Center · LB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aims: In light of the inconclusive evidence on the association between vitamin C status and colorectal cancer (CRC) outcome, this study assessed the prognostic value of vitamin C in participants with metastatic CRC (mCRC). Methods: Adults with mCRC and cancer-free controls were recruited in this prospective cohort study to allow for comparison of vitamin C levels with healthy individuals from the same population. Sociodemographic, lifestyle, medical variables, BRAF and KRAS mutations, as well as Vitamin C plasma level and food intake were evaluated. Predictors of diminished vitamin C level were assessed Results: The cancer group ( Conclusion: mCRC patients have lower plasma vitamin C levels than healthy controls. The trend toward higher mortality in the vitamin C deficient cancer group was not statistically significant. Whether this phenomenon affects survival and response to treatment warrants further exploration in phase III clinical trials.

Indexed as

colorectal cancermortalityplasmaprogressionvitamin C

Identifiers

PMID36969825
PMCPMC10038077
OpenAlexW4323315654

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read39
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.