Evidence map›Paper›PMID 36970405›Full record

ArticleFrontiers in chemistry2023

Analysis of 2'-hydroxyflavanone (2HF) in mouse whole blood by HPLC-MS/MS for the determination of pharmacokinetic parameters.

Luiza F O Gervazoni, Gabriella Gonçalves-Ozorio, Taiana Ferreira-Paes, Aline C A Silva, Gabriel P E Silveira, Heliana M Pereira, Douglas P Pinto, Edézio F Cunha-Junior, Elmo E Almeida-Amaral

Open access · goldFull text read
In one paragraph

Article in Frontiers in chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 68% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Luiza F O GervazoniLaboratório de Bioquímica de Tripanosomatídeos, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Gabriella Gonçalves-OzorioLaboratório de Bioquímica de Tripanosomatídeos, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Taiana Ferreira-PaesLaboratório de Bioquímica de Tripanosomatídeos, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Aline C A SilvaLaboratório de Farmacocinética, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Gabriel P E SilveiraLaboratório de Farmacocinética, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Heliana M PereiraLaboratório de Farmacocinética, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Douglas P PintoLaboratório de Farmacocinética, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Edézio F Cunha-JuniorLaboratório de Imunoparasitologia, Unidade Integrada de Pesquisa em Produtos Bioativos e Biociên-cias, Universidade Federal do Rio de Janeiro, Campus UFRJ, Macaé, Brazil.
Elmo E Almeida-AmaralLaboratório de Bioquímica de Tripanosomatídeos, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Fundação Oswaldo Cruz · BRUniversidade Federal do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Given the lack of investments, structure, and difficulty of metabolite isolation, promising natural product studies do not progress to preclinical studies, such as pharmacokinetics. 2'-Hydroxyflavanone (2HF) is a flavonoid that has shown promising results in different types of cancer and leishmaniasis. For accurate quantification of 2HF in BALB/c mouse blood, a validated HPLC-MS/MS method was developed. Chromatographic analysis was performed using C

Indexed as

2′-hydroxiflavanoneflavonoidHPLC-MS/MSoral treatmentpharmacokinetics

Identifiers

PMID36970405
PMCPMC10033538
OpenAlexW4323666203

What Socratic holds

Textfull text, public
LicenceCC BY
reference markers read2
measurements read62
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.