Evidence map›Paper›PMID 36970416›Full record

ArticleFrontiers in cellular neuroscience2023

Spontaneous neurotransmission at evocable synapses predicts their responsiveness to action potentials.

Andreas T Grasskamp, Meida Jusyte, Anthony W McCarthy, Torsten W B Götz, Susanne Ditlevsen, Alexander M Walter

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Article in Frontiers in cellular neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Frequency of Spontaneous Neurotransmission at Individual Boutons Corresponds to the Size of the Readily Releasable Pool of Vesicles.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Andreas T GrasskampLeibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany.
Meida JusyteLeibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany.
Anthony W McCarthyLeibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany.
Torsten W B GötzLeibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany.
Susanne DitlevsenDepartment of Mathematical Sciences, University of Copenhagen, Copenhagen, Denmark.
Alexander M WalterLeibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synaptic transmission relies on presynaptic neurotransmitter (NT) release from synaptic vesicles (SVs) and on NT detection by postsynaptic receptors. Transmission exists in two principal modes: action-potential (AP) evoked and AP-independent, "spontaneous" transmission. AP-evoked neurotransmission is considered the primary mode of inter-neuronal communication, whereas spontaneous transmission is required for neuronal development, homeostasis, and plasticity. While some synapses appear dedicated to spontaneous transmission only, all AP-responsive synapses also engage spontaneously, but whether this encodes functional information regarding their excitability is unknown. Here we report on functional interdependence of both transmission modes at individual synaptic contacts of

Indexed as

action potential evoked synaptic transmissionactive zoneDrosophila melanogasterphilanthotoxinspontaneous synaptic transmission

Identifiers

PMID36970416
PMCPMC10030884

What Socratic holds

Textfull text, public
LicenceCC BY
reference markers read1
measurements read53
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.