Evidence map›Paper›PMID 36970523›Full record

ArticleFrontiers in neurology2023

Evidence of polygenic regulation of the physiological presence of neurofilament light chain in human serum.

Marisol Herrera-Rivero, Edith Hofer, Aleksandra Maceski, David Leppert, Pascal Benkert, Jens Kuhle, Reinhold Schmidt, Michael Khalil, Heinz Wiendl, Monika Stoll and 1 more

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 4 countries.

Marisol Herrera-RiveroDepartment of Genetic Epidemiology, Institute of Human Genetics, University of Münster, Münster, Germany.
Edith HoferDepartment of Neurology, Medical University of Graz, Graz, Austria.
Aleksandra MaceskiNeurologic Clinic and Polyclinic, MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital of Basel, Basel, Switzerland.
David LeppertNeurologic Clinic and Polyclinic, MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital of Basel, Basel, Switzerland.
Pascal BenkertClinical Trial Unit, Department of Clinical Research, University Hospital of Basel, Basel, Switzerland.
Jens KuhleNeurologic Clinic and Polyclinic, MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital of Basel, Basel, Switzerland.
Reinhold SchmidtDepartment of Neurology, Medical University of Graz, Graz, Austria.
Michael KhalilDepartment of Neurology, Medical University of Graz, Graz, Austria.
Heinz WiendlDepartment of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.
Monika StollDepartment of Genetic Epidemiology, Institute of Human Genetics, University of Münster, Münster, Germany.
Klaus BergerInstitute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
University Hospital of Basel · CHMedical University of Graz · ATUniversity of Münster · DEMaastricht University · NLUniversity Hospital Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The measurement of neurofilament light chain (NfL) in blood is a promising biomarker of neurological injury and disease. We investigated the genetic factors that underlie serum NfL levels (sNfL) of individuals without neurological conditions. Methods: We performed a discovery genome-wide association study (GWAS) of sNfL in participants of the German BiDirect Study ( Results: Our discovery GWAS identified 12 genomic loci at the suggestive threshold (( Discussion: Our findings suggest that polygenic regulation of neuronal processes, inflammation, metabolism and clearance modulate the variability of NfL in the circulation. These could aid in the interpretation of sNfL measurements in a personalized manner.

Indexed as

geneticsGWASneurofilament light chainneuropathologyserum biomarkers

Identifiers

PMID36970523
PMCPMC10030935
OpenAlexW4323566898

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read16
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.