Evidence map›Paper›PMID 36973530›Full record

ArticleChinese journal of integrative medicine2023

Effects of Tanreqing Injection on ICU Mortality among ICU Patients Receiving Mechanical Ventilation: Time-Dependent Cox Regression Analysis of A Large Registry.

Wen Wang, Qiao He, Ming-Qi Wang, Jia-Yue Xu, Peng Ji, Rui Zhang, Kang Zou, Xin Sun

Abstract read
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In one paragraph

Article in Chinese journal of integrative medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wen WangChinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Chengdu, 610041, China.
Qiao HeChinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Chengdu, 610041, China.
Ming-Qi WangChinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Chengdu, 610041, China.
Jia-Yue XuChinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Chengdu, 610041, China.
Peng JiIntensive Care Unit, West China Hospital, Sichuan University, Chengdu, 610041, China.
Rui ZhangInformation Center, West China Hospital, Sichuan University, Chengdu, 610041, China.
Kang ZouChinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Chengdu, 610041, China.
Xin SunChinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Chengdu, 610041, China. sunxin@wchscu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo assess whether the use of Tanreqing (TRQ) Injection could show improvements in time to extubation, intensive care unit (ICU) mortality, ventilator-associated events (VAEs) and infection-related ventilator associated complication (IVAC) among patients receiving mechanical ventilation (MV).

methodsA time-dependent cox-regression analysis was conducted using data from a well-established registry of healthcare-associated infections at ICUs in China. Patients receiving continuous MV for 3 days or more were included. A time-varying exposure definition was used for TRQ Injection, which were recorded on daily basis. The outcomes included time to extubation, ICU mortality, VAEs and IVAC. Time-dependent Cox models were used to compare the clinical outcomes between TRQ Injection and non-use, after controlling for the influence of comorbidities/conditions and other medications with both fixed and time-varying covariates. For the analyses of time to extubation and ICU mortality, Fine-Gray competing risk models were also used to measure competing risks and outcomes of interest.

resultsOverall, 7,685 patients were included for the analyses of MV duration, and 7,273 patients for the analysis of ICU mortality. Compared to non-use, patients with TRQ Injection had a lower risk of ICU mortality (Hazards ratios (HR) 0.761, 95% CI, 0.581-0.997), and was associated with a higher hazard for time to extubation (HR 1.105, 95% CI, 1.005-1.216), suggesting a beneficial effect on shortened time to extubation. No significant differences were observed between TRQ Injection and non-use regarding VAEs (HR 1.057, 95% CI, 0.912-1.225) and IVAC (HR 1.177, 95% CI, 0.929-1.491). The effect estimates were robust when using alternative statistic models, applying alternative inclusion and exclusion criteria, and handling missing data by alternative approaches.

conclusionOur findings suggested that the use of TRQ Injection might lower mortality and improve time to extubation among patients receiving MV, even after controlling for the factor that the use of TRQ changed over time.

Indexed as

Intensive Care UnitsRespiration, ArtificialDrugs, Chinese HerbalHumansLength of StayProportional Hazards ModelsRegistriesDrugs, Chinese Herbaltanreqingcritical caremechanical ventilationmortalityTanreqingventilator-associated events

Identifiers

PMID36973530

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.