Evidence map›Paper›PMID 36973644›Full record

ArticleBMC cardiovascular disorders2023

Time-resolved simulation of blood flow through left anterior descending coronary artery: effect of varying extent of stenosis on hemodynamics.

Yinghong Zhao, Huihui Wang, Wenbing Chen, Wenyue Sun, Xianchao Yu, Cunjie Sun, Gang Hua

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Yinghong Zhao *China University of Mining and Technology, No.1, Daxue Road, Xuzhou, Jiangsu, China. zyh121@163.com.
Huihui Wang *Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu, China.
Wenbing ChenShenzhen University, Shenzhen, Guangdong, China.
Wenyue SunXuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu, China.
Xianchao YuSchool of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Cunjie SunThe Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
Gang HuaChina University of Mining and Technology, No.1, Daxue Road, Xuzhou, Jiangsu, China. huagangkuangda@163.com.
Xuzhou Medical College · CNChina University of Mining and Technology · CNShenzhen University · CNUniversity of Electronic Science and Technology of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesReal-time blood flow variation is crucial for understanding the dynamic development of coronary atherosclerosis. The main objective of this study is to investigate the effect of varying extent of stenosis on the hemodynamic features in left anterior descending coronary artery.

methodsVarious Computational fluid dynamics (CFD) models were constructed with patient-specific CT image data, using actual fractional flow reserve (FFR) as boundary conditions to provide a real-time quantitative description of hemodynamic properties. The hemodynamic parameters, such as the local and instantaneous wall shear stress (WSS), oscillating shear index (OSI) and relative residence time (RRT), blood flow velocity and pressure drop during various phases of cardiac cycle were provided in detail.

resultsThere was no evident variation in hemodynamic parameters in the cases of less than 50% stenosis while there were abrupt and dramatic changes in hemodynamics when the stenosis aggravated from 60 to 70%. Furthermore, when the stenosis was beyond 70%, there existed substantial pressure difference, WSS, and blood flow velocity in the center of the stenosis. Although OSI and RRT increased along with the aggravation of stenosis, they appeared with obvious abnormalities across all cases, even in mild stenosis.

conclusionThe simulation could present a dynamic and comprehensive profile of how hemodynamic parameters vary in accordance with divergent severities of stenosis, which could serve as an effective reference for the clinicians to have a deeper insight into the pathological mechanism of coronary atherosclerosis and stenosis.

Indexed as

Coronary Artery DiseaseCoronary StenosisFractional Flow Reserve, MyocardialBlood Flow VelocityConstriction, PathologicCoronary VesselsHemodynamicsHumansModels, CardiovascularStress, MechanicalCFDHemodynamicsLeft anterior descending coronary arteriesSimulationStenosis

Identifiers

PMID36973644
PMCPMC10041719
OpenAlexW4361008462

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read127
table measurements read42
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.