ReviewAlzheimer's & dementia : the journal of the Alzheimer's Association2023
APOE and immunity: Research highlights.
Open access · hybridAbstract readReview
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Review in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
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Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- Divergent biological consequences of APOE isoforms across industrialized and non-industrial environments.PLoS genetics · 2026Article
- β-glucan elicits APOE-dependent peripheral trained immunity to suppress hepatocellular carcinoma.Journal for immunotherapy of cancer · 2026Article
- Neurodegenerative diseases and immune system: From pathogenic mechanism to therapy.Neural regeneration research · 2026Article
- Metabolic Reprogramming of Microglia in Neuroinflammation and Depression.International journal of molecular sciences · 2026Review
- Molecular characterization of humanized APOE mouse models reveals source and genotype dependent differences.Molecular neurodegeneration · 2026Article
- APOE-mediated lipid transport prevents C1q-related synaptic loss after spinal cord injury via attenuating macrophage lipid stress.Journal of neuroinflammation · 2026Article
- Organelle stress in NLRP3 inflammasome: a central mediator of neurodegenerative diseases.Molecular neurodegeneration · 2026Review
- Apolipoprotein E drives microglia activation in the development of autoimmune uveitis through up-regulation of peptidyl prolyl isomerase F.Science advances · 2026Article
- Apolipoprotein E promoted the proliferation and function of group 2 innate lymphoid cells through low density lipoprotein receptor in allergic rhinitis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Article
- ApoE Inhibits the Progression of Glioma by Activating Immune Function.Journal of cellular and molecular medicine · 2025Article
- KChIP3 fosters neuroinflammation and synaptic dysfunction in the 5XFAD mouse model of Alzheimer's disease.Journal of neuroinflammation · 2025Article
- Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025Article
- Immunity in neuromodulation: probing neural and immune pathways in brain disorders.Journal of neuroinflammation · 2025Review
- Advancements in Immunity and Dementia Research: Highlights from the 2023 AAIC Advancements: Immunity Conference.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- The Activation of Muscarinic Acetylcholine Receptors Protects against Neuroinflammation in a Mouse Model through Attenuating Microglial Inflammation.International journal of molecular sciences · 2024Article
- Analyzing the Role of Specific Damage-Associated Molecular Patterns-Related Genes in Osteoarthritis and Investigating the Association between β-Amyloid and Apolipoprotein E Isoforms.Journal of innate immunity · 2024Article
- Urinary SPP1 has potential as a non-invasive diagnostic marker for focal segmental glomerulosclerosis.FEBS open bio · 2023Article
- Alteration of Blood Immune Biomarkers in MCI Patients with DifferentInternational journal of molecular sciences · 2023Article
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Authors and funding
40 authors at 20 institutions in 6 countries.
Courtney M KloskeAlzheimer's Association, Chicago, Illinois, USA.
Christopher J BarnumINmune Bio, Inc, La Jolla, California, USA.
Andre F BatistaDepartment of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Elizabeth M BradshawDepartment of Neurology, Columbia University Irving Medical Center, New York, New York, USA.
Adam M BrickmanTaub Institute for Research on Alzheimer's Disease and the Aging Brain, G.H. Sergievsky Center, and Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Guojun BuDepartment of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.
Jessica DennisonDepartment of Psychiatry & Behavioral Sciences, University of Miami Miller School of Medicine, Miami, Florida, USA.
Mary D GearonDepartment of Physiology, University of Kentucky, Lexington, Kentucky, USA.
Alison M GoateDepartment of Genetics & Genomic Sciences, Ronald M. Loeb Center for Alzheimer's disease, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Christian HaassMetabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, LMU Munich, Munich, Germany.
Michael T HenekaLuxembourg Centre for Systems Biomedicine (LCSB) University of Luxembourg, Esch-sur-Alzette, Luxembourg.
William T HuDepartment of Neurology, Rutgers-Robert Wood Johnson Medical School and Center for Healthy Aging, Rutgers Institute for Health, Health Care Policy, and Aging Research, New Brunswick, New Jersey, USA.
Lenique K L HugginsDepartment of Biology, Duke University, Durham, North Carolina, USA.
Nahdia S JonesInterdisciplinary Program in Neuroscience, Georgetown University, Washington, District of Columbia, USA.
Radosveta KoldamovaEOH, School of Public Health University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Cynthia A LemereDepartment of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Shane A LiddelowNeuroscience Institute and Departments of Neuroscience & Physiology and of Ophthalmology, NYU Grossman School of Medicine, New York, New York, USA.
Edoardo MarcoraRonald M. Loeb Center for Alzheimer's disease, Dept. of Genetics & Genomic Sciences, Dept. of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Samuel E MarshF.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, USA.
Henrietta M NielsenDepartment of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
Kellen K PetersenThe Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA.
Melissa PetersenDepartment of Family Medicine, Institute of Translational Research, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Stefanie D Piña-EscuderoGlobal Brain Health Institute, Department of Neurology, University of California, San Francisco, California, USA.
Wei Qiao QiuBoston University School of Medicine, Boston, Massachusetts, USA.
Yakeel T QuirozDepartments of Psychiatry and Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Eric ReimanBanner Alzheimer's Institute, Phoenix, Arizona, USA.
Claire SextonAlzheimer's Association, Chicago, Illinois, USA.ORCID 0000-0002-3846-2986
Malú Gámez TanseyDepartment of Neuroscience and Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida, USA.
Julia TcwDepartment of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts, USA.
Charlotte E TeunissenNeurochemistry Laboratory, Clinical Chemistry department, Amsterdam Neuroscience, Program Neurodegeneration, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Betty M TijmsAlzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.
Rik van der KantDepartment of Functional Genomics, Center for Neurogenomics and Cognitive Research (CNCR), VU University Amsterdam, Amsterdam, The Netherlands.
Rebecca WallingsCTRND, Department of Neuroscience, University of Florida, Florida, USA.
Stacie C WeningerFBRI, Cambridge, Massachusetts, USA.
Whitney WhartonSchool of Nursing, EmoryUniversity, Atlanta, Georgia, USA.
Donna M WilcockSanders-Brown Center on Aging and Department of Physiology, University of Kentucky, Lexington, Kentucky, USA.
Tyler James WishardPsychiatry & Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California, USA.
Susan L WorleyIndependent science writer, Bryn Mawr, Pennsylvania, USA.
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Maria C CarrilloAlzheimer's Association, Chicago, Illinois, USA.
Alzheimer's Association · USAmsterdam Neuroscience · NLBoston University · USBrigham and Women's Hospital · USIcahn School of Medicine at Mount Sinai · USUniversity of Florida · USUniversity of Kentucky · USAlbert Einstein College of Medicine · USBroad Institute · USBryn Mawr College · USColumbia University · USColumbia University Irving Medical Center · USDuke University · USEmory University · USGeorgetown University · USGerman Center for Neurodegenerative Diseases · DEHarvard University · USJacksonville College · USLa Jolla Bioengineering Institute · USNeurosciences Institute · US
Funding
Project 4 (Genetic modifiers for APOE-associated Alzheimer's disease pathogenesis)U19AG069701 · NIA · MAYO CLINIC JACKSONVILLE · PI Yingxue Ren · 2021 to 2026
$42.0MAPOE in the Predisposition to, Protection from and Prevention of Alzheimer's DiseaseR01AG069453 · NIA · BANNER HEALTH · PI ASHTON, NICHOLAS, LANGBAUM, JESSICA BROOKE · 2020 to 2025
$27.4MStrategies for Targeting Astrocyte Reactivity in Alzheimer's Disease and Related DementiasP01AG078116 · NIA · UNIVERSITY OF KENTUCKY · PI PETER T. NELSON · 2022 to 2026
$25.0MResearch Education ComponentP30AG072980 · NIA · BANNER HEALTH · PI HEATHER Allyson BIMONTE-NELSON · 2021 to 2026
$24.9MTraining in the Molecular Biology of Neurodegeneration and Alzheimer's DiseaseT32AG000222 · NIA · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Bruce A YANKNER · 1992 to 2026
$18.5MMulti-omic network-directed proteoform discovery, dissection and functional validation to prioritize novel AD therapeutic targetsU01AG061356 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BENNETT, DAVID ALAN, DE JAGER, PHILIP L · 2018 to 2022
$13.7MRutgers-NYU Center for Asian Health Promotion and EquityP50MD017356 · NIMHD · RUTGERS BIOMEDICAL/HEALTH SCIENCES-RBHS · PI WU, BEI · 2021 to 2025
$11.6MDevelopment of PU.1 Inhibitory Modulators as Novel Therapeutics for Alzheimer's DiseaseU01AG066757 · NIA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GOATE, ALISON M, RAY, WILLIAM J · 2020 to 2024
$8.0MThe Role of Intracranial Atherosclerosis in the Development of Alzheimer's DiseaseR01AG054491 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI WASSERMAN, BRUCE A · 2016 to 2021
$6.4MNeuroprotective signaling and transcriptional pathways in microglia associated with Alzheimer's diseaseR01AG072489 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ALISON M GOATE, Anne Schaefer · 2022 to 2026
$6.3MThe University of Kentucky MarkVCID Biomarker Validation Cohort: Development of a Toolbox to Advance VCID Interventional StudiesUF1NS125488 · NINDS · UNIVERSITY OF KENTUCKY · PI JICHA, GREGORY A, WILCOCK, DONNA M · 2021 to 2023
$6.1MGenomic approach to identification of microglial networks involved in Alzheimer’s disease riskU01AG058635 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GOATE, ALISON M · 2018 to 2022
$4.8MNEI NIH HHS R01 EY033353NIAAA NIH HHS R01 AA016829NIA NIH HHS P01 AG078116NIA NIH HHS P30 AG059304NIA NIH HHS P30 AG072980NIA NIH HHS R01 AG007992NIA NIH HHS R01 AG027924NIA NIH HHS R01 AG046205NIA NIH HHS R01 AG054005NIA NIH HHS R01 AG054046NIA NIH HHS R01 AG054491NIA NIH HHS R01 AG066198NIA NIH HHS R01 AG066203NIA NIH HHS R01 AG066395NIA NIH HHS R01 AG067581NIA NIH HHS R01 AG069453NIA NIH HHS R01 AG072489NIA NIH HHS R01 AG076018NIA NIH HHS R01 AG077636NIA NIH HHS R21 AG073882NIA NIH HHS R24 AG063729NIA NIH HHS R24 AG066599NIA NIH HHS R37 AG027924NIA NIH HHS RF1 AG046205NIA NIH HHS RF1 AG057181NIA NIH HHS RF1 AG058657NIA NIH HHS RF1 AG058852NIA NIH HHS RF1 AG060057NIA NIH HHS RF1 AG075832NIA NIH HHS RF1 AG075992NIA NIH HHS T32 AG000222NIA NIH HHS U01 AG058635NIA NIH HHS U01 AG061356NIA NIH HHS U01 AG066757NIA NIH HHS U19 AG069701NIMHD NIH HHS P50 MD017356NINDS NIH HHS R01 NS116990NINDS NIH HHS RF1 NS130834NINDS NIH HHS UF1 NS125488
Abstract
introductionAt the Alzheimer's Association's APOE and Immunity virtual conference, held in October 2021, leading neuroscience experts shared recent research advances on and inspiring insights into the various roles that both the apolipoprotein E gene (APOE) and facets of immunity play in neurodegenerative diseases, including Alzheimer's disease and other dementias.
methodsThe meeting brought together more than 1200 registered attendees from 62 different countries, representing the realms of academia and industry.
resultsDuring the 4-day meeting, presenters illuminated aspects of the cross-talk between APOE and immunity, with a focus on the roles of microglia, triggering receptor expressed on myeloid cells 2 (TREM2), and components of inflammation (e.g., tumor necrosis factor α [TNFα]). DISCUSSION: This manuscript emphasizes the importance of diversity in current and future research and presents an integrated view of innate immune functions in Alzheimer's disease as well as related promising directions in drug development.
Indexed as
Alzheimer DiseaseApolipoproteins EHumansInflammationMicrogliaApolipoproteins EAlzheimer's diseaseamyloid betaAPOEastrocytesbiomarkersdementiainflammationmicroglianeurodegenerationneuroglianeuroinflammationtauTREM2
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.