Evidence map›Paper›PMID 36976056›Full record

ReviewJournal of functional biomaterials2023

Autologous Tooth Graft: Innovative Biomaterial for Bone Regeneration. Tooth Transformer

Angelo Michele Inchingolo, Assunta Patano, Chiara Di Pede, Alessio Danilo Inchingolo, Giulia Palmieri, Elisabetta de Ruvo, Merigrazia Campanelli, Silvio Buongiorno, Vincenzo Carpentiere, Fabio Piras and 17 more

Abstract readReview
In one paragraph

Review in Journal of functional biomaterials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Angelo Michele InchingoloDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0003-0104-6337
Assunta PatanoDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0001-7395-3126
Chiara Di PedeDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0002-7465-9567
Alessio Danilo InchingoloDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0002-6366-1039
Giulia PalmieriDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0003-0292-1965
Elisabetta de RuvoDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.
Merigrazia CampanelliDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0001-8445-5384
Silvio BuongiornoDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.
Vincenzo CarpentiereDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0002-3579-7342
Fabio PirasDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0003-0765-7710
Vito SettanniDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0003-4145-3455
Fabio ViapianoDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.
Denisa HazballaDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0002-8160-3342
Biagio RaponeDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0002-0062-6594
Antonio ManciniDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0002-7103-4086
Daniela Di VenereDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0002-6916-0075
Francesco InchingoloDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0003-3797-5883
Maria Celeste FatonePTA Trani-ASL BT, Viale Padre Pio, 76125 Trani, Italy.ORCID 0000-0001-7666-8179
Andrea PalermoCollege of Medicine and Dentistry Birmingham, University of Birmingham, Birmingham B4 6BN, UK.ORCID 0000-0002-3288-490X
Elio MinettiDepartment of Biomedical, Surgical, and Dental Science, Università Degli Studi di Milano, 20122 Milan, Italy.ORCID 0000-0002-4151-8063
Felice LorussoDepartment of Innovative Technologies in Medicine and Dentistry, University of Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0002-2660-9231
Antonio ScaranoDepartment of Innovative Technologies in Medicine and Dentistry, University of Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0003-1374-6146
Salvatore SauroDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0002-2527-8776
Gianluca Martino TartagliaDepartment of Biomedical, Surgical and Dental Sciences, School of Dentistry, University of Milan, 20100 Milan, Italy.ORCID 0000-0001-7062-5143
Ioana Roxana BordeaDepartment of Oral Rehabilitation, Faculty of Dentistry, Iuliu Hațieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.ORCID 0000-0001-7166-9949
Gianna DipalmaDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0002-5947-8987
Giuseppina MalcangiDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0001-9745-7506

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Different biomaterials, from synthetic products to autologous or heterologous grafts, have been suggested for the preservation and regeneration of bone. The aim of this study is to evaluate the effectiveness of autologous tooth as a grafting material and examine the properties of this material and its interactions with bone metabolism. PubMed, Scopus, Cochrane Library, and Web of Science were searched to find articles addressing our topic published from 1 January 2012 up to 22 November 2022, and a total of 1516 studies were identified. Eighteen papers in all were considered in this review for qualitative analysis. Demineralized dentin can be used as a graft material, since it shows high cell compatibility and promotes rapid bone regeneration by striking an ideal balance between bone resorption and production; it also has several benefits, such as quick recovery times, high-quality newly formed bone, low costs, no risk of disease transmission, the ability to be performed as an outpatient procedure, and no donor-related postoperative complications. Demineralization is a crucial step in the tooth treatment process, which includes cleaning, grinding, and demineralization. Since the presence of hydroxyapatite crystals prevents the release of growth factors, demineralization is essential for effective regenerative surgery. Even though the relationship between the bone system and dysbiosis has not yet been fully explored, this study highlights an association between bone and gut microbes. The creation of additional scientific studies to build upon and enhance the findings of this study should be a future objective of scientific research.

Indexed as

autologous graftbiomaterialsbone remodelingdemineralized dentine matrixmicrobiotamorphogenetic proteinsosteogenic materialregenerative dentistrytooth grafttooth transformer®

Identifiers

PMID36976056
PMCPMC10058341

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.