Evidence map›Paper›PMID 36976235›Full record

ArticleMarine drugs2023

Expanding the Chemical Space of Arsenicin A-C Related Polyarsenicals and Evaluation of Some Analogs as Inhibitors of Glioblastoma Stem Cell Growth.

Jacopo Vigna, Denise Sighel, Emanuele Filiberto Rosatti, Andrea Defant, Michael Pancher, Viktoryia Sidarovich, Alessandro Quattrone, Ines Mancini

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine drugs, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jacopo VignaLaboratory of Bioorganic Chemistry, Department of Physics, University of Trento, Via Sommarive 14, 38123 Trento, Italy.ORCID 0000-0003-4359-6951
Denise SighelLaboratory of Translational Genomics, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Via Sommarive 9, 38123 Trento, Italy.ORCID 0000-0002-4950-7254
Emanuele Filiberto RosattiLaboratory of Translational Genomics, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Via Sommarive 9, 38123 Trento, Italy.ORCID 0000-0002-6877-4948
Andrea DefantLaboratory of Bioorganic Chemistry, Department of Physics, University of Trento, Via Sommarive 14, 38123 Trento, Italy.
Michael PancherHigh Throughput Screening (HTS) and Validation Core Facility, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Via Sommarive 9, 38123 Trento, Italy.ORCID 0000-0002-3783-6069
Viktoryia SidarovichHigh Throughput Screening (HTS) and Validation Core Facility, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Via Sommarive 9, 38123 Trento, Italy.ORCID 0000-0002-2621-4977
Alessandro QuattroneLaboratory of Translational Genomics, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Via Sommarive 9, 38123 Trento, Italy.
Ines ManciniLaboratory of Bioorganic Chemistry, Department of Physics, University of Trento, Via Sommarive 14, 38123 Trento, Italy.ORCID 0000-0003-0297-3685
University of Trento · IT

Funding

University of Trento, 5X1000 campaign, project "Farmaci del Mare"; donation from Ivana and Enrico Zobele; Department CIBIO Core Facilities (HTS) supported by the European Regional Development Fund (ERDF) 2014-2020
6 · The paper itself

Abstract

The marine polyarsenical metabolite arsenicin A is the landmark of a series of natural and synthetic molecules characterized by an adamantane-like tetraarsenic cage. Arsenicin A and related polyarsenicals have been evaluated for their antitumor effects in vitro and have been proven more potent than the FDA-approved arsenic trioxide. In this context, we have expanded the chemical space of polyarsenicals related to arsenicin A by synthesizing dialkyl and dimethyl thio-analogs, the latter characterized with the support of simulated NMR spectra. In addition, the new natural arsenicin D, the scarcity of which in the

Indexed as

AdamantaneBrain NeoplasmsGlioblastomaArsenicalsArsenic TrioxideCell Line, TumorHumansStem CellsAdamantaneArsenicalsarsenicin AArsenic TrioxideADME predictionantitumorarsenic trioxideAs-S cagecalculated NMR spectrumcancer stem cellglioblastomahypoxiamarine metabolitepolyarsenical

Identifiers

PMID36976235
PMCPMC10051910
OpenAlexW4327974201

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.