Evidence map›Paper›PMID 36976312›Full record

ArticleMedicines (Basel, Switzerland)2023

Health Technology Assessment of Different Glucosamine Formulations and Preparations Currently Marketed in Thailand.

Olivier Bruyère, Johann Detilleux, Jean-Yves Reginster

Open access · goldAbstract read
In one paragraph

Article in Medicines (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Olivier BruyèreDivision of Public Health, Epidemiology and Health Economics, WHO Collaborating Centre for Epidemiology of Musculoskeletal Health and Ageing, University of Liège, 4000 Liège, Belgium.ORCID 0000-0003-4269-9393
Johann DetilleuxDepartment of Veterinary Management of Animal Resources, University of Liège, 4000 Liège, Belgium.
Jean-Yves ReginsterDivision of Public Health, Epidemiology and Health Economics, WHO Collaborating Centre for Epidemiology of Musculoskeletal Health and Ageing, University of Liège, 4000 Liège, Belgium.ORCID 0000-0001-6290-752X
University of Liège · BE

Funding

Mylan (United States) no number
6 · The paper itself

Abstract

objectiveThe aim of this study was to evaluate the cost-effectiveness of different glucosamine formulations and preparations used for the management of osteoarthritis in Thailand compared with placebo.

methodsWe used a validated model to simulate the individual patient Utility score from aggregated data available from 10 different clinical trials. We then used the Utility score to calculate the quality-adjusted life year (QALY) over 3 and 6 months treatment period. We used the public costs of glucosamine products available in Thailand in 2019 to calculate the incremental cost-effectiveness ratio. We separated the analyses for prescription-grade crystalline glucosamine sulfate (pCGS) and other formulations of glucosamine. A cost-effectiveness cut-off of 3.260 USD/QALY was considered.

resultsIrrespective of the glucosamine preparation (tablet or powder/capsule), the data show that pCGS is cost-effective compared with placebo over a 3 and 6 months. However, the other glucosamine formulations (e.g., glucosamine hydrochloride) never reached the breakeven point at any time.

conclusionsOur data show that pCGS is cost-effective for the management of osteoarthritis in the Thai context while other glucosamine formulations are not.

Indexed as

glucosaminehealth technology assessmentosteoarthritis

Identifiers

PMID36976312
PMCPMC10059797
OpenAlexW4323668438

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.