Evidence map›Paper›PMID 36976764›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Whole-brain mapping of histaminergic projections in mouse brain.

Wenkai Lin, Lingyu Xu, Yanrong Zheng, Sile An, Mengting Zhao, Weiwei Hu, Mengyao Li, Hui Dong, Anan Li, Yulong Li and 5 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Mast Cells in the Developing Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Review
  3. Article
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  7. Review
  8. Metabolomics of cerebrospinal fluid following traumatic brain injury: Exploration of biomarkers for secondary injuries and severity.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
  9. Article
  10. Targeting Histamine H4 Receptor in the Rostral Ventromedial Medulla to Relieve Hypertension.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  11. Article
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  16. Article
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  18. Article
  19. Histamine HNeuroscience bulletin · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

Wenkai LinInstitute of Pharmacology and Toxicology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0003-2568-9257
Lingyu XuInstitute of Pharmacology and Toxicology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Yanrong ZhengKey Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Sile AnBritton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Ministry of Education Key Laboratory for Biomedical Photonics, Huazhong University of Science and Technology, Wuhan 430074, China.
Mengting ZhaoBritton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Ministry of Education Key Laboratory for Biomedical Photonics, Huazhong University of Science and Technology, Wuhan 430074, China.ORCID 0000-0003-2037-9129
Weiwei HuInstitute of Pharmacology and Toxicology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0002-7768-6907
Mengyao LiState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China.
Hui DongState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China.ORCID 0000-0002-0563-3662
Anan LiHuazhong University of Science and Technology-Suzhou Institute for Brainsmatics, Jiangsu Industrial Technology Research Institute for Brainsmatics, Suzhou 215000, China.ORCID 0000-0002-5877-4813
Yulong LiState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China.ORCID 0000-0002-9166-9919
Hui GongHuazhong University of Science and Technology-Suzhou Institute for Brainsmatics, Jiangsu Industrial Technology Research Institute for Brainsmatics, Suzhou 215000, China.
Gang PanDepartment of Computer Science, Zhejiang University, Hangzhou 310058, China.
Yi WangInstitute of Pharmacology and Toxicology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0002-1350-2961
Qingming LuoKey Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan University, Haikou 570228, China.
Zhong ChenInstitute of Pharmacology and Toxicology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0003-4755-9357
Zhejiang Chinese Medical University · CNPeking University · CNZhejiang University · CNSuzhou Research Institute · CNWuhan National Laboratory for Optoelectronics · CNHainan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Histamine is a conserved neuromodulator in mammalian brains and critically involved in many physiological functions. Understanding the precise structure of the histaminergic network is the cornerstone in elucidating its function. Herein, using histidine decarboxylase (HDC)-CreERT2 mice and genetic labeling strategies, we reconstructed a whole-brain three dimensional (3D) structure of histaminergic neurons and their outputs at 0.32 × 0.32 × 2 μm

Indexed as

BrainHistamineAnimalsBrain MappingHistidine DecarboxylaseMammalsMiceNeuronsHistamineHistidine DecarboxylasefMOSThistaminergic networkhistaminergic neuronswhole-brain map

Identifiers

PMID36976764
PMCPMC10083611
OpenAlexW4361215120

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.