ArticleProceedings of the National Academy of Sciences of the United States of America2023
Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium.
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In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
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55citing papers in PubMed, 3 pooled it
13.2field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 3 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Sex differences in schizophrenia: symptomatology, treatment efficacy and adverse effects.Frontiers in psychiatry · 2025Pooled it
- Prevalence of spontaneous movement disorders (dyskinesia, parkinsonism, akathisia and dystonia) in never-treated patients with chronic and first-episode psychosis: a systematic review and meta-analysis.BMJ mental health · 2024Pooled it
- Retina as a potential biomarker in schizophrenia spectrum disorders: a systematic review and meta-analysis of optical coherence tomography and electroretinography.Molecular psychiatry · 2024Pooled it
- Cerebral cortical alterations in adolescent early-onset psychosis: a surface-based morphometry mega-analysis.Molecular psychiatry · 2026Article
- 7T magnetic resonance spectroscopic imaging of subcortical neurometabolites across antipsychotic treatment in acutely symptomatic early-phase schizophrenia spectrum disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Replicable subcortical alterations linked to neurological soft signs in schizophrenia spectrum disorders.Psychological medicine · 2026Article
- Fixation Task: A Simple Eye Movement Task Reveals an Impairment in Schizophrenia.Schizophrenia bulletin · 2026Article
- Widespread synaptic density loss in schizophrenia follows molecular and network architecture.Molecular psychiatry · 2026Article
- Inter- and intra-hemispheric lateralization alterations in auditory verbal hallucinations of Schizophrenia: insights from resting-state functional connectivity.European archives of psychiatry and clinical neuroscience · 2026Article
- Age-Dependent Corpus Callosum Thickness Abnormalities and Clinical Implications in Treatment-Naïve First-Episode Schizophrenia.Alpha psychiatry · 2026Article
- Left and Right Hemispheric Lateralization as an Overlooked Variable in Psychiatric Disease: Evidence Across Species.Biological psychiatry · 2026Review
- Individualized cortical thickness asymmetry in autism spectrum disorder and schizophrenia.Molecular psychiatry · 2026Article
- Structural and functional brain asymmetry in relation to heterogeneous causes of situs inversus totalis.Brain structure & function · 2026Article
- Reassessing Asymmetry Reduction in Psychosis: Cingulate Folding and Gyrification Covariance in Patients with Auditory Hallucinations.Schizophrenia bulletin · 2026Article
- Non-right-handedness and psychiatric disorders: A synthesis of epidemiological, genetic, and neurobiological evidence.World journal of psychiatry · 2026Review
- Relationship between N100 amplitude and T1w/T2w-ratio in the auditory cortex in schizophrenia spectrum disorders.Schizophrenia (Heidelberg, Germany) · 2026Article
- Prefrontal Structural Asymmetry Mediates Body Mass Index and Treatment Response in Major Depressive Disorder.Depression and anxiety · 2026Article
- Schizophrenia.Nature reviews. Disease primers · 2025Review
- Motor dysfunction, social context and early prodromal features of psychosis: historical acumen, developmental pathobiology and early intervention.Schizophrenia (Heidelberg, Germany) · 2025Article
- The molecular and cellular underpinnings of human brain lateralization.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
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Authors and funding
149 authors at 20 institutions in 20 countries.
Dick SchijvenLanguage & Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen 6525 XD, The Netherlands.ORCID 0000-0001-5190-7241
Merel C PostemaLanguage & Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen 6525 XD, The Netherlands.
Masaki FukunagaDivision of Cerebral Integration, National Institute for Physiological Sciences, Okazaki 444-8585, Japan.ORCID 0000-0003-1010-2644
Junya MatsumotoDepartment of Pathology of Mental Diseases, National Center of Neurology and Psychiatry, National Institute of Mental Health, Tokyo 187-8551, Japan.ORCID 0000-0003-4228-3208
Kenichiro MiuraDepartment of Pathology of Mental Diseases, National Center of Neurology and Psychiatry, National Institute of Mental Health, Tokyo 187-8551, Japan.
Sonja M C de ZwarteDepartment of Psychiatry, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht 3584 CG, The Netherlands.
Neeltje E M van HarenDepartment of Psychiatry, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht 3584 CG, The Netherlands.
Wiepke CahnDepartment of Psychiatry, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht 3584 CG, The Netherlands.
Hilleke E Hulshoff PolDepartment of Psychiatry, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht 3584 CG, The Netherlands.
René S KahnDepartment of Psychiatry, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht 3584 CG, The Netherlands.
Rosa Ayesa-ArriolaDepartment of Psychiatry, Instituto de Investigación Marqués de Valdecilla, University Hospital Marqués de Valdecilla, Santander 39008, Spain.
Víctor Ortiz-García de la FozCentro de Investigación Biomédica en Red de Salud Mental, Instituto de Salud Carlos III, Madrid 28029, Spain.ORCID 0000-0002-0627-1827
Diana Tordesillas-GutierrezDepartment of Radiology, Instituto de Investigación Marqués de Valdecilla, Marqués de Valdecilla University Hospital, Santander 39011, Spain.ORCID 0000-0003-1458-3932
Javier Vázquez-BourgonDepartment of Psychiatry, Instituto de Investigación Marqués de Valdecilla, University Hospital Marqués de Valdecilla, Santander 39008, Spain.ORCID 0000-0002-5478-3376
Benedicto Crespo-FacorroCentro de Investigación Biomédica en Red de Salud Mental, Instituto de Salud Carlos III, Madrid 28029, Spain.
Dag AlnæsNorwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo 0450, Norway.ORCID 0000-0001-7361-5418
Andreas DahlDepartment of Psychology, University of Oslo, Oslo 0373, Norway.
Lars T WestlyeNorwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo 0450, Norway.ORCID 0000-0001-8644-956X
Ingrid AgartzNorwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo 0450, Norway.
Ole A AndreassenNorwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo 0450, Norway.ORCID 0000-0002-4461-3568
Erik G JönssonNorwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo 0450, Norway.
Peter KochunovDepartment of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201.
Jason M BruggemannSchool of Psychiatry, University of New South Wales, Sydney 2033, Australia.
Stanley V CattsSchool of Medicine, The University of Queensland, Brisbane 4006, Australia.
Patricia T MichieSchool of Psychological Sciences, University of Newcastle, Newcastle 2308, Australia.
Bryan J MowryQueensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.
Yann QuidéSchool of Psychiatry, University of New South Wales, Sydney 2033, Australia.
Paul E RasserCentre for Brain and Mental Health Research, University of Newcastle, Newcastle 2308, Australia.ORCID 0000-0003-3482-721X
Ulrich SchallCentre for Brain and Mental Health Research, University of Newcastle, Newcastle 2308, Australia.ORCID 0000-0001-9041-4562
Rodney J ScottSchool of Biomedical Science and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Newcastle 2308, Australia.ORCID 0000-0001-7724-3404
Vaughan J CarrSchool of Psychiatry, University of New South Wales, Sydney 2033, Australia.
Melissa J GreenSchool of Psychiatry, University of New South Wales, Sydney 2033, Australia.
Frans A HenskensSchool of Medicine and Public Health, University of Newcastle, Newcastle 2308, Australia.ORCID 0000-0003-2358-5630
Carmel M LoughlandSchool of Medicine and Public Health, University of Newcastle, Newcastle 2308, Australia.
Christos PantelisMelbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Melbourne 3053, Australia.ORCID 0000-0002-9565-0238
Cynthia Shannon WeickertSchool of Psychiatry, University of New South Wales, Sydney 2033, Australia.
Thomas W WeickertSchool of Psychiatry, University of New South Wales, Sydney 2033, Australia.
Lieuwe de HaanEarly Psychosis Department, Department of Psychiatry, Amsterdam UMC (location AMC), Amsterdam 1105 AZ, The Netherlands.
Katharina BroschDepartment of Psychiatry and Psychotherapy, Philipps-Universität Marburg, Marburg 35039, Germany.ORCID 0000-0002-0526-8095
Julia-Katharina PfarrDepartment of Psychiatry and Psychotherapy, Philipps-Universität Marburg, Marburg 35039, Germany.
Kai G RingwaldDepartment of Psychiatry and Psychotherapy, Philipps-Universität Marburg, Marburg 35039, Germany.
Frederike SteinDepartment of Psychiatry and Psychotherapy, Philipps-Universität Marburg, Marburg 35039, Germany.
Andreas JansenDepartment of Psychiatry and Psychotherapy, Philipps-Universität Marburg, Marburg 35039, Germany.
Tilo T J KircherDepartment of Psychiatry and Psychotherapy, Philipps-Universität Marburg, Marburg 35039, Germany.
Igor NenadićDepartment of Psychiatry and Psychotherapy, Philipps-Universität Marburg, Marburg 35039, Germany.
Bernd KrämerDepartment of General Psychiatry, Section for Experimental Psychopathology and Neuroimaging, Heidelberg University, Heidelberg 69115, Germany.ORCID 0000-0002-1145-9103
Oliver GruberDepartment of General Psychiatry, Section for Experimental Psychopathology and Neuroimaging, Heidelberg University, Heidelberg 69115, Germany.ORCID 0000-0003-1841-7413
Theodore D SatterthwaiteDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.ORCID 0000-0001-7072-9399
Juan BustilloDepartment of Psychiatry and Neuroscience, University of New Mexico, Albuquerque, NM 87106.
Daniel H MathalonDepartment of Psychiatry and Behavioral Sciences and Weill Institute for Neurosciences, University of California, San Francisco, CA 94143.
Adrian PredaDepartment of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA 92697.
Vince D CalhounPsychology Department and Neuroscience Institute, Georgia State University, Atlanta, GA 30303.ORCID 0000-0001-9058-0747
Judith M FordSan Francisco VA Medical Center, University of California, San Francisco, CA 94121.ORCID 0000-0002-6500-6548
Steven G PotkinDepartment of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA 92697.
Jingxu ChenBeijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing 100096, P.R. China.
Yunlong TanBeijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing 100096, P.R. China.ORCID 0000-0002-3522-3912
Zhiren WangBeijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing 100096, P.R. China.
Hong XiangChongqing University Three Gorges Hospital, Chongqing 404188, P.R. China.
Fengmei FanBeijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing 100096, P.R. China.
Fabio BernardoniDivision of Psychological and Social Medicine and Developmental Neurosciences, Translational Developmental Neuroscience Section, Technische Universität Dresden, University Hospital C.G. Carus, Dresden 01307, Germany.
Stefan EhrlichDivision of Psychological and Social Medicine and Developmental Neurosciences, Translational Developmental Neuroscience Section, Technische Universität Dresden, University Hospital C.G. Carus, Dresden 01307, Germany.ORCID 0000-0003-2132-4445
Paola Fuentes-ClaramonteFIDMAG Germanes Hospitalàries Research Foundation, Barcelona 08035, Spain.ORCID 0000-0002-1428-7976
Maria Angeles Garcia-LeonFIDMAG Germanes Hospitalàries Research Foundation, Barcelona 08035, Spain.
Amalia Guerrero-PedrazaFIDMAG Germanes Hospitalàries Research Foundation, Barcelona 08035, Spain.
Raymond SalvadorFIDMAG Germanes Hospitalàries Research Foundation, Barcelona 08035, Spain.ORCID 0000-0001-5557-1562
Salvador SarróFIDMAG Germanes Hospitalàries Research Foundation, Barcelona 08035, Spain.ORCID 0000-0003-1835-2189
Edith Pomarol-ClotetFIDMAG Germanes Hospitalàries Research Foundation, Barcelona 08035, Spain.
Valentina CiulloLaboratory of Neuropsychiatry, Istituto di Ricovero e Cura a Carattere Scientifico Santa Lucia Foundation, Rome 00179, Italy.ORCID 0000-0002-6870-6259
Fabrizio PirasLaboratory of Neuropsychiatry, Istituto di Ricovero e Cura a Carattere Scientifico Santa Lucia Foundation, Rome 00179, Italy.
Daniela VecchioLaboratory of Neuropsychiatry, Istituto di Ricovero e Cura a Carattere Scientifico Santa Lucia Foundation, Rome 00179, Italy.
Nerisa BanajLaboratory of Neuropsychiatry, Istituto di Ricovero e Cura a Carattere Scientifico Santa Lucia Foundation, Rome 00179, Italy.
Gianfranco SpallettaLaboratory of Neuropsychiatry, Istituto di Ricovero e Cura a Carattere Scientifico Santa Lucia Foundation, Rome 00179, Italy.ORCID 0000-0002-7432-4249
Stijn MichielseDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht University, Maastricht 6229 ER, The Netherlands.
Therese van AmelsvoortDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht University, Maastricht 6229 ER, The Netherlands.
Erin W DickieCampbell Family Mental Health Institute, Centre for Addiction and Mental Health, Toronto M5S 2S1, Canada.
Aristotle N VoineskosCampbell Family Mental Health Institute, Centre for Addiction and Mental Health, Toronto M5S 2S1, Canada.ORCID 0000-0003-0156-0395
Kang SimWest Region, Institute of Mental Health, Singapore 539747, Singapore.ORCID 0000-0003-3209-9626
Simone CiufoliniDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, United Kingdom.
Paola DazzanDepartment of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, United Kingdom.
Robin M MurrayDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, United Kingdom.ORCID 0000-0003-0829-0519
Woo-Sung KimDepartment of Psychiatry, Jeonbuk National University Medical School, Jeonju 54896, Republic of Korea.
Young-Chul ChungDepartment of Psychiatry, Jeonbuk National University Medical School, Jeonju 54896, Republic of Korea.
Christina AndreouDepartment of Psychiatry, University Psychiatric Clinics (Universitäre Psychiatrische Kliniken), University of Basel, Basel 4002, Switzerland.
André SchmidtDepartment of Psychiatry, University Psychiatric Clinics (Universitäre Psychiatrische Kliniken), University of Basel, Basel 4002, Switzerland.
Stefan BorgwardtDepartment of Psychiatry, University Psychiatric Clinics (Universitäre Psychiatrische Kliniken), University of Basel, Basel 4002, Switzerland.
Andrew M McIntoshDivision of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom.
Heather C WhalleyDivision of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom.
Stephen M LawrieDivision of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom.ORCID 0000-0002-2444-5675
Stefan du PlessisDepartment of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch 7505, South Africa.
Hilmar K LuckhoffDepartment of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch 7505, South Africa.
Freda SchefflerDepartment of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch 7505, South Africa.ORCID 0000-0002-8898-8599
Robin EmsleyDepartment of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch 7505, South Africa.
Dominik GrotegerdInstitute for Translational Psychiatry, Westfälische Wilhelms-Universität Münster, Münster 48149, Germany.
Rebekka LencerDepartment of Psychiatry and Psychotherapy, University of Lübeck, Lübeck 23562, Germany.
Udo DannlowskiInstitute for Translational Psychiatry, Westfälische Wilhelms-Universität Münster, Münster 48149, Germany.
Jesse T EdmondPsychology Department and Neuroscience Institute, Georgia State University, Atlanta, GA 30303.
Kelly Rootes-MurdyPsychology Department and Neuroscience Institute, Georgia State University, Atlanta, GA 30303.
Julia M StephenThe Mind Research Network, Albuquerque, NM 87106.
Andrew R MayerThe Mind Research Network, Albuquerque, NM 87106.
Linda A AntonucciDepartment of Education, Psychology, Communication, University of Bari Aldo Moro, Bari 70121, Italy.
Leonardo FazioDepartment of Basic Medical Science, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari 70121, Italy.ORCID 0000-0003-4000-974X
Giulio PergolaDepartment of Basic Medical Science, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari 70121, Italy.ORCID 0000-0002-9193-1841
Alessandro BertolinoDepartment of Basic Medical Science, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari 70121, Italy.
Covadonga M Díaz-CanejaDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Madrid 28009, Spain.
Joost JanssenDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Madrid 28009, Spain.
Noemi G LoisDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Madrid 28009, Spain.ORCID 0000-0002-6600-072X
Celso ArangoDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Madrid 28009, Spain.
Alexander S TomyshevLaboratory of Neuroimaging and Multimodal Analysis, Mental Health Research Center, Moscow 115522, Russian Federation.
Irina LebedevaLaboratory of Neuroimaging and Multimodal Analysis, Mental Health Research Center, Moscow 115522, Russian Federation.
Simon CervenkaCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm 113 64, Sweden.
Carl M SellgrenCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm 113 64, Sweden.
Foivos GeorgiadisDepartment of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich (PUK), Zurich 8008, Switzerland.
Matthias KirschnerDepartment of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich (PUK), Zurich 8008, Switzerland.
Stefan KaiserDepartment of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich (PUK), Zurich 8008, Switzerland.
Tomas HajekNational Institute of Mental Health, Klecany 250 67, Czech Republic.
Antonin SkochNational Institute of Mental Health, Klecany 250 67, Czech Republic.ORCID 0000-0002-1739-3256
Filip SpanielNational Institute of Mental Health, Klecany 250 67, Czech Republic.
Minah KimDepartment of Neuropsychiatry, Seoul National University Hospital, Seoul 08826, Republic of Korea.ORCID 0000-0001-8668-0817
Yoo Bin KwakDepartment of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul 08826, Republic of Korea.
Sanghoon OhDepartment of Psychiatry, Seoul National University College of Medicine, Seoul 08826, Republic of Korea.ORCID 0000-0002-7394-5211
Jun Soo KwonDepartment of Neuropsychiatry, Seoul National University Hospital, Seoul 08826, Republic of Korea.
Anthony JamesDepartment of Psychiatry, University of Oxford, Oxford OX3 7JX, United Kingdom.ORCID 0000-0002-2742-8328
Geor BakkerDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht University, Maastricht 6229 ER, The Netherlands.
Christian KnöchelDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main 60528, Germany.
Michael StäbleinDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main 60528, Germany.
Viola OertelDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main 60528, Germany.
Anne UhlmannDepartment of Psychiatry and Mental Health, Faculty of Health Sciences, University of Cape Town, Cape Town 7935, South Africa.ORCID 0000-0002-1753-7811
Fleur M HowellsDepartment of Psychiatry and Mental Health, Faculty of Health Sciences, University of Cape Town, Cape Town 7935, South Africa.
Dan J SteinDepartment of Psychiatry and Mental Health, Faculty of Health Sciences, University of Cape Town, Cape Town 7935, South Africa.ORCID 0000-0001-7218-7810
Henk S TemminghDepartment of Psychiatry and Mental Health, Faculty of Health Sciences, University of Cape Town, Cape Town 7935, South Africa.ORCID 0000-0002-7688-0759
Ana M Diaz-ZuluagaDepartment of Psychiatry, Research Group in Psychiatry (GIPSI), Faculty of Medicine, Universidad de Antioquia, Medellín 050010, Colombia.
Julian A Pineda-ZapataDepartment of Psychiatry, Research Group in Psychiatry (GIPSI), Faculty of Medicine, Universidad de Antioquia, Medellín 050010, Colombia.
Carlos López-JaramilloDepartment of Psychiatry, Research Group in Psychiatry (GIPSI), Faculty of Medicine, Universidad de Antioquia, Medellín 050010, Colombia.
Stephanie HomanDepartment of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich (PUK), Zurich 8008, Switzerland.
Ellen JiDepartment of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich (PUK), Zurich 8008, Switzerland.
Werner SurbeckDepartment of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich (PUK), Zurich 8008, Switzerland.
Philipp HomanDepartment of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich (PUK), Zurich 8008, Switzerland.ORCID 0000-0001-9034-148X
Simon E FisherLanguage & Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen 6525 XD, The Netherlands.ORCID 0000-0002-3132-1996
Barbara FrankeDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen 6500 HB, The Netherlands.ORCID 0000-0003-4375-6572
David C GlahnDepartment of Psychiatry, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115.ORCID 0000-0002-4749-6977
Ruben C GurDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.ORCID 0000-0002-9657-1996
Ryota HashimotoDepartment of Pathology of Mental Diseases, National Center of Neurology and Psychiatry, National Institute of Mental Health, Tokyo 187-8551, Japan.
Neda JahanshadImaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033.
Eileen LudersSchool of Psychology, University of Auckland, Auckland 1010, New Zealand.ORCID 0000-0001-5659-992X
Sarah E MedlandPsychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane 4006, Australia.
Paul M ThompsonImaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033.ORCID 0000-0002-4720-8867
Jessica A TurnerPsychology Department and Neuroscience Institute, Georgia State University, Atlanta, GA 30303.
Theo G M van ErpClinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA 92697.
Clyde FrancksLanguage & Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen 6525 XD, The Netherlands.ORCID 0000-0002-9098-890X
Philipps University of Marburg · DECentro de Investigación Biomédica en Red de Salud Mental · ESUtrecht University · NLFondazione Santa Lucia · ITPeking University · CNRadboud University Nijmegen · NLSeoul National University · KRUniversity of Bari Aldo Moro · ITUniversity of Cape Town · ZAUniversity of Oslo · NOGoethe University Frankfurt · DEKing's College London · GBMaastricht University Medical Centre · NLNational Center of Neurology and Psychiatry · JPUniversidad de Antioquia · COUniversidad de Cantabria · ESUniversity of Basel · CHUniversity of California, Irvine · USUniversity of Edinburgh · GBUniversity of Münster · DE
Funding
Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Hisashi Umemori · 2021 to 2026
$9.4MSOLAR-Eclipse Computational Tools for Imaging GeneticsR01EB015611 · NIBIB · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KOCHUNOV, PETER V. · 2012 to 2024
$5.0MRedefine Trans-Neuropsychiatric Disorder Brain Patterns through Big-Data and Machine LearningRF1MH123163 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI KOCHUNOV, PETER V., THOMPSON, PAUL M · 2021 to 2021
$1.2MHybrid GPU/CPU Computing Resource to Support Connectomic and GenomicsS10OD023696 · OD · UNIVERSITY OF MARYLAND BALTIMORE · PI KOCHUNOV, PETER V. · 2018 to 2018
$593kMedical Research Council G0500092NIBIB NIH HHS R01 EB015611NICHD NIH HHS P50 HD105351NIH HHS S10 OD023696NIMH NIH HHS RF1 MH123163
Abstract
Left-right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting in equivocal findings. We carried out the largest case-control study of structural brain asymmetries in schizophrenia, with MRI data from 5,080 affected individuals and 6,015 controls across 46 datasets, using a single image analysis protocol. Asymmetry indexes were calculated for global and regional cortical thickness, surface area, and subcortical volume measures. Differences of asymmetry were calculated between affected individuals and controls per dataset, and effect sizes were meta-analyzed across datasets. Small average case-control differences were observed for thickness asymmetries of the rostral anterior cingulate and the middle temporal gyrus, both driven by thinner left-hemispheric cortices in schizophrenia. Analyses of these asymmetries with respect to the use of antipsychotic medication and other clinical variables did not show any significant associations. Assessment of age- and sex-specific effects revealed a stronger average leftward asymmetry of pallidum volume between older cases and controls. Case-control differences in a multivariate context were assessed in a subset of the data (N = 2,029), which revealed that 7% of the variance across all structural asymmetries was explained by case-control status. Subtle case-control differences of brain macrostructural asymmetry may reflect differences at the molecular, cytoarchitectonic, or circuit levels that have functional relevance for the disorder. Reduced left middle temporal cortical thickness is consistent with altered left-hemisphere language network organization in schizophrenia.
Indexed as
SchizophreniaBrainCase-Control StudiesCerebral CortexFemaleFunctional LateralityHumansMagnetic Resonance ImagingMaleasymmetrybrain imagingcorticalSchizophreniasubcortical
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