Evidence map›Paper›PMID 36976770›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Acute phosphatidylinositol 4,5 bisphosphate depletion destabilizes sarcolemmal expression of cardiac L-type Ca

Taylor L Voelker, Silvia G Del Villar, Maartje Westhoff, Alexandre D Costa, Andrea M Coleman, Johannes W Hell, Mary C Horne, Eamonn J Dickson, Rose E Dixon

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. CaThe Journal of physiology · 2026
    Article
  2. PIP4K attenuates PIP5K lipid kinase activity by disrupting membrane-mediated dimerization.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. α1Journal of the American Heart Association · 2024
    Article
  8. NPC1-dependent alterations in KNature communications · 2023
    Article
  9. αeLife · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Taylor L VoelkerDepartment of Physiology and Membrane Biology, School of Medicine, University of California Davis, Davis, CA 95616.ORCID 0000-0002-6779-9350
Silvia G Del VillarDepartment of Physiology and Membrane Biology, School of Medicine, University of California Davis, Davis, CA 95616.ORCID 0000-0002-5612-4761
Maartje WesthoffDepartment of Physiology and Membrane Biology, School of Medicine, University of California Davis, Davis, CA 95616.ORCID 0000-0002-5421-8609
Alexandre D CostaDepartment of Physiology and Membrane Biology, School of Medicine, University of California Davis, Davis, CA 95616.
Andrea M ColemanDepartment of Pharmacology, School of Medicine, University of California Davis, Davis, CA 95616.
Johannes W HellDepartment of Pharmacology, School of Medicine, University of California Davis, Davis, CA 95616.ORCID 0000-0001-7960-7531
Mary C HorneDepartment of Pharmacology, School of Medicine, University of California Davis, Davis, CA 95616.ORCID 0000-0002-2799-3212
Eamonn J DicksonDepartment of Physiology and Membrane Biology, School of Medicine, University of California Davis, Davis, CA 95616.ORCID 0000-0001-8619-7630
Rose E DixonDepartment of Physiology and Membrane Biology, School of Medicine, University of California Davis, Davis, CA 95616.ORCID 0000-0003-0655-690X
University of California, Davis · US

Funding

UC Davis Biology ProgramR25GM056765 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI GOMES, ALDRIN V. · 1998 to 2019
$9.7M
Molecular choreography of CaV1.2 channels in the aging myocardiumR01AG063796 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Rose Ellen Dixon · 2019 to 2026
$3.1M
Lipid regulation of Cardiac Excitation-Contraction couplingR01HL159304 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DIXON, ROSE ELLEN · 2022 to 2025
$2.4M
Postsynaptic Signaling by Norepinephrine and cAMPR01NS123050 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JOHANNES W HELL · 2022 to 2026
$2.3M
Predoctoral Training in Pharmacological SciencesT32GM099608 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HELL, JOHANNES W · 2012 to 2021
$2.2M
Dysregulation of Cav1.2 by beta amyloid peptideRF1AG055357 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HELL, JOHANNES W · 2022 to 2024
$1.7M
Membrane contact sites regulate cellular excitabilityR01GM127513 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DICKSON, EAMONN JAMES · 2019 to 2023
$1.6M
UC Davis Training Program in Chemical BiologyT32GM113770 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BEAL, PETER A. · 2015 to 2019
$742k
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL159304HHS | NIH | National Institute of General Medical Sciences (NIGMS) R01GM127513HHS | NIH | National Institute of General Medical Sciences (NIGMS) R25GM056765HHS | NIH | National Institute of General Medical Sciences (NIGMS) T32GM099608HHS | NIH | National Institute of General Medical Sciences (NIGMS) T32GM113770HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS123050HHS | NIH | National Institute on Aging (NIA) R01AG063796HHS | NIH | National Institute on Aging (NIA) RF1AG055357NHLBI NIH HHS R01 HL159304NIA NIH HHS R01 AG063796NIA NIH HHS RF1 AG055357NIGMS NIH HHS R01 GM127513NIGMS NIH HHS R25 GM056765NIGMS NIH HHS T32 GM099608NIGMS NIH HHS T32 GM113770NINDS NIH HHS R01 NS123050
6 · The paper itself

Abstract

Ca

Indexed as

Angiotensin IIExcitation Contraction CouplingCalcium Channels, L-TypeCells, CulturedMyocytes, CardiacPhosphatidylinositol 4,5-DiphosphateSignal TransductionAngiotensin IICalcium Channels, L-TypePhosphatidylinositol 4,5-Diphosphateangiotensin IIEC-couplingion channel traffickingL-type calcium channelsPIP2

Identifiers

PMID36976770
PMCPMC10083594
OpenAlexW4361218625

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.