Evidence map›Paper›PMID 36977142›Full record

ArticleTropical medicine and infectious disease2023

Leishmanicidal Activity of Guanidine Derivatives against

Fernanda Silva Almeida, Vitor Partite Moreira, Edson Dos Santos Silva, Leonardo Lima Cardoso, Pedro Henrique de Sousa Palmeira, Luiz Henrique Agra Cavalcante-Silva, Demétrius A M de Araújo, Ian P G do Amaral, Eduardo René Pérez González, Tatjana S L Keesen

Open access · goldAbstract read
In one paragraph

Article in Tropical medicine and infectious disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Antifungal activity of guanidine compounds.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025
    Article
  6. Galegine, a Bioprivileged Alkaloid fromCurrent topics in medicinal chemistry · 2025
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Fernanda Silva AlmeidaImmunology of Infectious Diseases Laboratory of Department of Cellular and Molecular Biology; Federal University of Paraiba, João Pessoa 58051-900, PB, Brazil.
Vitor Partite MoreiraDepartment of Chemistry and Biochemistry, Fine Organic Chemistry Lab, School of Sciences and Technology, São Paulo State University (UNESP), Presidente Prudente 19060-080, SP, Brazil.
Edson Dos Santos SilvaImmunology of Infectious Diseases Laboratory of Department of Cellular and Molecular Biology; Federal University of Paraiba, João Pessoa 58051-900, PB, Brazil.
Leonardo Lima CardosoImmunology of Infectious Diseases Laboratory of Department of Cellular and Molecular Biology; Federal University of Paraiba, João Pessoa 58051-900, PB, Brazil.ORCID 0000-0003-4924-0542
Pedro Henrique de Sousa PalmeiraImmunology of Infectious Diseases Laboratory of Department of Cellular and Molecular Biology; Federal University of Paraiba, João Pessoa 58051-900, PB, Brazil.ORCID 0000-0002-9323-7677
Luiz Henrique Agra Cavalcante-SilvaImmunology of Infectious Diseases Laboratory of Department of Cellular and Molecular Biology; Federal University of Paraiba, João Pessoa 58051-900, PB, Brazil.ORCID 0000-0002-8445-5189
Demétrius A M de AraújoDepartment of Biotechnology, Universidade Federal da Paraíba, João Pessoa 58051-900, PB, Brazil.
Ian P G do AmaralLaboratory of Biochemistry, Department of Cellular and Molecular Biology; Federal University of Paraiba, João Pessoa 58051-900, PB, Brazil.
Eduardo René Pérez GonzálezDepartment of Chemistry and Biochemistry, Fine Organic Chemistry Lab, School of Sciences and Technology, São Paulo State University (UNESP), Presidente Prudente 19060-080, SP, Brazil.ORCID 0000-0003-1348-8554
Tatjana S L KeesenImmunology of Infectious Diseases Laboratory of Department of Cellular and Molecular Biology; Federal University of Paraiba, João Pessoa 58051-900, PB, Brazil.ORCID 0000-0003-0964-389X
Universidade Federal da Paraíba · BRUniversidade Estadual Paulista (Unesp) · BR

Funding

Fundação de Apoio a Pesquisa do Estado da Paraíba (FAPESQ)/CAPES grant number 23038.004264/2015-03
6 · The paper itself

Abstract

Leishmaniasis is a neglected tropical infectious disease with thousands of cases annually; it is of great concern to global health, particularly the most severe form, visceral leishmaniasis. Visceral leishmaniasis treatments are minimal and have severe adverse effects. As guanidine-bearing compounds have shown antimicrobial activity, we analyzed the cytotoxic effects of several guanidine-bearing compounds on

Indexed as

anti-leishmanial activityapoptosiscell deathguanidine compoundsLeishmaniasisnitrite production

Identifiers

PMID36977142
PMCPMC10051705
OpenAlexW4322503711

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.