Evidence map›Paper›PMID 36977890›Full record

SynthesisObesity surgery2023

Role of Tranexamic Acid (TXA) in Preventing Bleeding Following Sleeve Gastrectomy: a Systematic Review and Meta-analysis.

Valentin Mocanu, Hillary Wilson, Kevin Verhoeff, Janice Kung, Caolan Walsh, Nicole Koloszvari, Amy Neville, Shahzeer Karmali

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Obesity surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 3 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Valentin MocanuDepartment of Surgery, University of Alberta Hospital, University of Alberta, 8440 112 Street NW, Edmonton, AB, T6G 2B7, Canada. Vmocanu1987@gmail.com.ORCID http://orcid.org/0000-0001-7855-6242
Hillary WilsonDepartment of Medicine, University of Alberta Hospital, University of Alberta, 8440 112 Street NW, Edmonton, AB, T6G 2B7, Canada.
Kevin VerhoeffDepartment of Surgery, University of Alberta Hospital, University of Alberta, 8440 112 Street NW, Edmonton, AB, T6G 2B7, Canada.
Janice KungMLIS John W. Scott Health Sciences Library, University of Alberta, Mackenzie Health Sciences Centre, 2K3.28 Walter C, Edmonton, AB, Canada.
Caolan WalshCenter for Foregut, Bariatric, and Minimally Invasive Surgery, The Ottawa Hospital, Ottawa, ON, Canada.
Nicole KoloszvariCenter for Foregut, Bariatric, and Minimally Invasive Surgery, The Ottawa Hospital, Ottawa, ON, Canada.
Amy NevilleCenter for Foregut, Bariatric, and Minimally Invasive Surgery, The Ottawa Hospital, Ottawa, ON, Canada.
Shahzeer KarmaliCentre for Advancement of Surgical Education and Simulation (CASES), Royal Alexandra Hospital, Edmonton, AB, Canada.
Ottawa Hospital · CAUniversity of Alberta Hospital · CARoyal Alexandra Hospital · CAUniversity of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTranexamic acid (TXA) has drawn growing interest over the last decade for its benefit in optimizing post-operative bleeding, yet its role in bariatric surgery is poorly understood.

methodsThe medical librarian developed and executed comprehensive searches on September 28, 2022. The population of interest included adults who underwent elective bariatric surgery. The intervention was tranexamic acid administration while the comparison was placebo or standard peri-operative therapy. The primary outcome of interest was post-operative bleeding which was defined a priori.

resultsA total of four studies were identified comprising of 475 patients. Of those, 207 (50%) received TXA at induction and all underwent laparoscopic sleeve gastrectomy (LSG). The majority of patients were female (n = 343, 80.7%) with ages ranging from 17 to 70 years of age and mean BMIs ranging from 37 to 56 kg/m

conclusionsIntravenous tranexamic acid at the time of laparoscopic sleeve gastrectomy is associated with a significant reduction of post-operative bleeding with no observed differences in thromboembolic events or mortality. Further high-quality studies are needed to better delineate the ideal bariatric population to receives TXA in addition to the optimal timing, dose, and duration of TXA therapy.

Indexed as

Antifibrinolytic AgentsObesity, MorbidTranexamic AcidVenous ThromboembolismAdolescentAdultAgedBlood Loss, SurgicalFemaleGastrectomyHumansMaleMiddle AgedPostoperative HemorrhageYoung AdultAntifibrinolytic AgentsTranexamic AcidBariatric surgeryBleedingMetabolic SurgerySleeve gastrectomyTranexamic acid

Identifiers

PMID36977890
OpenAlexW4361213819

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.