Evidence map›Paper›PMID 36978954›Full record

ArticleAntioxidants (Basel, Switzerland)2023

Ryanodine Receptor Mediated Calcium Release Contributes to Ferroptosis Induced in Primary Hippocampal Neurons by GPX4 Inhibition.

Silvia Gleitze, Omar A Ramírez, Ignacio Vega-Vásquez, Jing Yan, Pedro Lobos, Hilmar Bading, Marco T Núñez, Andrea Paula-Lima, Cecilia Hidalgo

Open access · goldFull text read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

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  12. Iron imbalance in neurodegeneration.Molecular psychiatry · 2024
    Review
  13. IPAntioxidants (Basel, Switzerland) · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Silvia GleitzeBiomedical Neuroscience Institute, Faculty of Medicine, Universidad de Chile, Santiago 8380000, Chile.
Omar A RamírezDepartment of Neurobiology, Interdisciplinary Center for Neurosciences (IZN), Heidelberg University, 69120 Heidelberg, Germany.ORCID 0000-0002-9326-2290
Ignacio Vega-VásquezBiomedical Neuroscience Institute, Faculty of Medicine, Universidad de Chile, Santiago 8380000, Chile.ORCID 0000-0002-7613-5919
Jing YanDepartment of Neurobiology, Interdisciplinary Center for Neurosciences (IZN), Heidelberg University, 69120 Heidelberg, Germany.
Pedro LobosBiomedical Neuroscience Institute, Faculty of Medicine, Universidad de Chile, Santiago 8380000, Chile.ORCID 0000-0002-0831-1079
Hilmar BadingDepartment of Neurobiology, Interdisciplinary Center for Neurosciences (IZN), Heidelberg University, 69120 Heidelberg, Germany.
Marco T NúñezDepartment of Biology, Faculty of Sciences, Universidad de Chile, Santiago 7810000, Chile.ORCID 0000-0002-1967-8570
Andrea Paula-LimaBiomedical Neuroscience Institute, Faculty of Medicine, Universidad de Chile, Santiago 8380000, Chile.ORCID 0000-0002-0466-7561
Cecilia HidalgoBiomedical Neuroscience Institute, Faculty of Medicine, Universidad de Chile, Santiago 8380000, Chile.ORCID 0000-0003-1256-9651
University of Chile · CLHeidelberg University · DE

Funding

ANID-BMBF 180051ANID-FONDECYT 1140545, 11140580, 1170058, 1190958ANID-FONDEQUIP 140156, 40156ANID, Millennium grants ICN09_015/ACE210007CONICYT-PhD-scholarships 21200346, 21161086
6 · The paper itself

Abstract

Ferroptosis, a newly described form of regulated cell death, is characterized by the iron-dependent accumulation of lipid peroxides, glutathione depletion, mitochondrial alterations, and enhanced lipoxygenase activity. Inhibition of glutathione peroxidase 4 (GPX4), a key intracellular antioxidant regulator, promotes ferroptosis in different cell types. Scant information is available on GPX4-induced ferroptosis in hippocampal neurons. Moreover, the role of calcium (Ca

Indexed as

calcium signalingcell deathdendritic morphologyendoplasmic reticulumferroptosisglutathione peroxidaseironiron chelatorslipid peroxidationneurodegenerationoxidative stressreactive oxygen speciesRSL3

Identifiers

PMID36978954
PMCPMC10045106
OpenAlexW4324056236

What Socratic holds

Textfull text, public
LicenceCC BY
reference markers read2
measurements read31
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.