Evidence map›Paper›PMID 36978989›Full record

ArticleAntioxidants (Basel, Switzerland)2023

Single-Cell Kinetic Modeling of β-Lapachone Metabolism in Head and Neck Squamous Cell Carcinoma.

Andrew D Raddatz, Cristina M Furdui, Erik A Bey, Melissa L Kemp

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Systems Biology of the Cancer Cell.Annual review of biomedical engineering · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Andrew D RaddatzWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta, GA 30332, USA.
Cristina M FurduiDepartment of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27101, USA.
Erik A BeyWood Hudson Cancer Research Laboratory, Newport, KY 41071, USA.
Melissa L KempWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta, GA 30332, USA.ORCID 0000-0003-3781-8802
Georgia Institute of Technology · USWake Forest University · USWood Hudson Cancer Research Laboratory · US

Funding

Model-based Prediction of Redox-Modulated Responses to Cancer TreatmentsU01CA215848 · NCI · GEORGIA INSTITUTE OF TECHNOLOGY · PI FURDUI, CRISTINA MARIA, KEMP, MELISSA LAMBETH · 2017 to 2021
$3.6M
T32 CTEng (Cellular and Tissue Engineering) Training ProgramT32GM145735 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI Edward A. Botchwey, Andres J Garcia · 2022 to 2026
$2.3M
NCI NIH HHS U01CA215848NIGMS NIH HHS T32GM145735
6 · The paper itself

Abstract

Head and neck squamous cell carcinoma (HNSCC) cells are highly heterogeneous in their metabolism and typically experience elevated reactive oxygen species (ROS) levels such as superoxide and hydrogen peroxide (H

Indexed as

head and neck squamous cell carcinomaredox biologyROSscRNA-seqsystems modelingβ-lapachone

Identifiers

PMID36978989
PMCPMC10045120
OpenAlexW4327740825

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read7
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.