Evidence map›Paper›PMID 36979333›Full record

ArticleBrain sciences2023

Antidepressant Activities of Synthesized Benzodiazepine Analogues in Mice.

Faizan Ul Haq, Mohammad Shoaib, Syed Wadood Ali Shah, Haya Hussain, Muhammad Zahoor, Riaz Ullah, Ahmed Bari, Amal Alotaibi, Muhammad Faisal Hayat

Open access · goldFull text read
In one paragraph

Article in Brain sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Faizan Ul HaqDepartment of Pharmacy, University of Malakand, Chakdara, Lower Dir 18800, Khyber Pakhtunkhwa, Pakistan.
Mohammad ShoaibDepartment of Pharmacy, University of Malakand, Chakdara, Lower Dir 18800, Khyber Pakhtunkhwa, Pakistan.
Syed Wadood Ali ShahDepartment of Pharmacy, University of Malakand, Chakdara, Lower Dir 18800, Khyber Pakhtunkhwa, Pakistan.ORCID 0000-0001-8143-2363
Haya HussainDepartment of Pharmacy, Shaheed Benazir Bhutto University, Sheringal 18000, Khyber Pakhtunkhwa, Pakistan.ORCID 0000-0001-6121-5441
Muhammad ZahoorDepartment of Biochemistry, University of Malakand, Chakdara, Lower Dir 18800, Khyber Pakhtunkhwa, Pakistan.ORCID 0000-0002-4528-8517
Riaz UllahMedicinal Aromatic and Poisonous Plants Research Center, Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Ahmed BariDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0002-9447-2361
Amal AlotaibiDepartment of Basic Science, College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia.ORCID 0000-0001-9819-447X
Muhammad Faisal HayatNorth West Institute of Health and Sciences, Peshawar 25100, Khyber Pakhtunkhwa, Pakistan.
University of Malakand · PKKing Saud University · SAPrincess Nourah bint Abdulrahman University · SAShaheed Benazir Bhutto University · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Depression is a serious psychological disorder which negatively affects human feelings and actions. The use of antidepressants is the therapy of choice while treating depression. However, such drugs are associated with severe side effects. There is a need for efficient and harmless drugs. In this connection, the present study was designed to synthesize several substituted benzodiazepine derivatives and explore their antidepressant potentials in an animal model. The chalcone backbone was initially synthesized, which was then converted into several substituted benzodiazepine derivatives designated as

Indexed as

antidepressantsbenzodiazepinesdepressionforced swim testGABAergic systemhydroxychalconestail suspension test

Identifiers

PMID36979333
PMCPMC10046342
OpenAlexW4353063361

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read38
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.