ArticleBiomolecules2023
Diversity of HLA-A2-Restricted and Immunodominant Epitope Repertoire of Human T-Lymphotropic Virus Type 1 (HTLV-1) Tax Protein: Novel Insights among N-Terminal, Central and C-Terminal Regions.
Thaiza Aline Pereira-Santos, Anderson Santos da Rocha, Ágata Lopes-Ribeiro, Laura Cardoso Corrêa-Dias, Patrícia Melo-Oliveira, Erik Vinicius de Sousa Reis, Flávio Guimarães da Fonseca, Edel Figueiredo Barbosa-Stancioli, Moriya Tsuji, Jordana Grazziela Alves Coelho-Dos-Reis
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In one paragraphArticle in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
10 authors at 2 institutions in 2 countries.
Thaiza Aline Pereira-SantosLaboratório de Virologia Básica e Aplicada (LVBA), Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil.ORCID 0000-0002-8661-6599 Anderson Santos da RochaLaboratório de Virologia Básica e Aplicada (LVBA), Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil.
Ágata Lopes-RibeiroLaboratório de Virologia Básica e Aplicada (LVBA), Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil.
Laura Cardoso Corrêa-DiasLaboratório de Virologia Básica e Aplicada (LVBA), Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil.ORCID 0000-0002-8286-7083 Patrícia Melo-OliveiraLaboratório de Virologia Básica e Aplicada (LVBA), Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil.
Erik Vinicius de Sousa ReisLaboratório de Virologia Básica e Aplicada (LVBA), Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil.ORCID 0000-0001-5442-6240 Flávio Guimarães da FonsecaLaboratório de Virologia Básica e Aplicada (LVBA), Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil.ORCID 0000-0002-1416-8694 Edel Figueiredo Barbosa-StancioliLaboratório de Virologia Básica e Aplicada (LVBA), Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil.
Moriya TsujiAaron Diamond AIDS Research Center, Division of Infectious Disease, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0001-8587-277X Jordana Grazziela Alves Coelho-Dos-ReisLaboratório de Virologia Básica e Aplicada (LVBA), Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil.ORCID 0000-0002-2360-1875 Universidade Federal de Minas Gerais · BRAaron Diamond AIDS Research Center · US
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
The present study sought to search for the immunodominance related to the N-terminal, Central and C-terminal regions of HTLV-1 Tax using novel, cutting-edge peptide microarray analysis. In addition, in silico predictions were performed to verify the presence of nine amino acid peptides present along Tax restricted to the human leukocyte antigen (HLA)-A2.02*01 haplotype, as well as to verify the ability to induce pro-inflammatory and regulatory cytokines, such as IFN-γ and IL-4, respectively. Our results indicated abundant dose-dependent reactivity for HLA-A*02:01 in all regions (N-terminal, Central and C-terminal), but with specific hotspots. Furthermore, the results of fold-change over the Tax
Indexed as
Human T-lymphotropic virus 1Gene Products, taxHLA-A2 AntigenHumansImmunodominant EpitopesInterleukin-4PeptidesT-Lymphocytes, CytotoxicGene Products, taxHLA-A2 AntigenImmunodominant EpitopesInterleukin-4PeptidesCD8+ T-cell responseHLA-A2 haplotypeHTLV-1immunodominanceimmunoinformaticsMHC-I peptidesTax
Identifiers
PMID36979478
PMCPMC10046496
OpenAlexW4327741040
What Socratic holds
Textfull text, public
LicenceCC BY
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