Evidence map›Paper›PMID 36979547›Full record

ReviewBiosensors2023

Review on Carbon Dot-Based Fluorescent Detection of Biothiols.

Muthaiah Shellaiah, Kien Wen Sun

Open access · goldFull text readReview
In one paragraph

Review in Biosensors, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 58 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Muthaiah ShellaiahDepartment of Applied Chemistry, National Yang Ming Chiao Tung University, Hsinchu 300, Taiwan.ORCID 0000-0002-2748-1735
Kien Wen SunDepartment of Applied Chemistry, National Yang Ming Chiao Tung University, Hsinchu 300, Taiwan.ORCID 0000-0002-2995-0283
National Yang Ming Chiao Tung University · TW

Funding

Ministry of Science and Technology, Taiwan MOST 111-2112-M-A49-031-Ministry of Science and Technology, Taiwan MOST 111-2811-M-A49-528
6 · The paper itself

Abstract

Biothiols, such as cysteine (Cys), homocysteine (Hcy), and glutathione (GSH), play a vital role in gene expression, maintaining redox homeostasis, reducing damages caused by free radicals/toxins, etc. Likewise, abnormal levels of biothiols can lead to severe diseases, such as Alzheimer's disease (AD), neurotoxicity, hair depigmentation, liver/skin damage, etc. To quantify the biothiols in a biological system, numerous low-toxic probes, such as fluorescent quantum dots, emissive organic probes, composited nanomaterials, etc., have been reported with real-time applications. Among these fluorescent probes, carbon-dots (CDs) have become attractive for biothiols quantification because of advantages of easy synthesis, nano-size, crystalline properties, low-toxicity, and real-time applicability. A CDs-based biothiols assay can be achieved by fluorescent "Turn-On" and "Turn-Off" responses via direct binding, metal complex-mediated detection, composite enhanced interaction, reaction-based reports, and so forth. To date, the availability of a review focused on fluorescent CDs-based biothiols detection with information on recent trends, mechanistic aspects, linear ranges, LODs, and real applications is lacking, which allows us to deliver this comprehensive review. This review delivers valuable information on reported carbon-dots-based biothiols assays, the underlying mechanism, their applications, probe/CDs selection, sensory requirement, merits, limitations, and future scopes.

Indexed as

Quantum DotsSulfhydryl CompoundsCarbonCysteineFluorescent DyesGlutathioneSpectrometry, FluorescenceCarbonCysteineFluorescent DyesGlutathioneSulfhydryl Compoundsbioassaybioimagingbiothiols detectioncarbon-dotscomplex-mediated sensorsfluorescencefluorescence quenchingnanocompositesone-pot synthesisreal analysis

Identifiers

PMID36979547
PMCPMC10046571
OpenAlexW4323047257

What Socratic holds

Textfull text, public
LicenceCC BY
reference markers read1
measurements read114
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.