Evidence map›Paper›PMID 36979602›Full record

ArticleBiosensors2023

Microfluidic Platform Integrated with Carbon Nanofibers-Decorated Gold Nanoporous Sensing Device for Serum PSA Quantification.

Emiliano Felici, Matías D Regiart, Sirley V Pereira, Francisco G Ortega, Lúcio Angnes, Germán A Messina, Martín A Fernández-Baldo

Open access · goldFull text read
In one paragraph

Article in Biosensors, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Emiliano FeliciFacultad de Química, Bioquímica y Farmacia, Instituto de Química de San Luis, INQUISAL (UNSL-CONICET), Universidad Nacional de San Luis, Chacabuco 917, San Luis D5700BWS, Argentina.
Matías D RegiartFacultad de Química, Bioquímica y Farmacia, Instituto de Química de San Luis, INQUISAL (UNSL-CONICET), Universidad Nacional de San Luis, Chacabuco 917, San Luis D5700BWS, Argentina.
Sirley V PereiraFacultad de Química, Bioquímica y Farmacia, Instituto de Química de San Luis, INQUISAL (UNSL-CONICET), Universidad Nacional de San Luis, Chacabuco 917, San Luis D5700BWS, Argentina.
Francisco G OrtegaGENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government PTS, Granada, Avenida de la Ilustración, 114, 18016 Granada, Spain.
Lúcio AngnesLaboratório de Automação e Instrumentação Analítica, Department of Fundamental Chemistry, Institute of Chemistry, University of São Paulo, Av. Professor Lineu Prestes 748, São Paulo 05508-000, Brazil.
Germán A MessinaFacultad de Química, Bioquímica y Farmacia, Instituto de Química de San Luis, INQUISAL (UNSL-CONICET), Universidad Nacional de San Luis, Chacabuco 917, San Luis D5700BWS, Argentina.
Martín A Fernández-BaldoFacultad de Química, Bioquímica y Farmacia, Instituto de Química de San Luis, INQUISAL (UNSL-CONICET), Universidad Nacional de San Luis, Chacabuco 917, San Luis D5700BWS, Argentina.ORCID 0000-0003-0385-2391
Consejo Nacional de Investigaciones Científicas y Técnicas · ARPfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research · ESUniversidade de São Paulo · BR

Funding

Agencia Nacional de Promoción Científica y Tecnológica PICT 2018-04443, PICT-2020-02347, PICT-2020-02369, PICT-2021-GRF-TI-00136National Scientific and Technical Research Council PIP11220200100033CONational University of San Luis PROICO 22/Q241Pfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research PI22/01275, PI19/01578University of Granada P32/22/02
6 · The paper itself

Abstract

Prostate cancer is a disease with a high incidence and mortality rate in men worldwide. Serum prostate-specific antigens (PSA) are the main circulating biomarker for this disease in clinical practices. In this work, we present a portable and reusable microfluidic device for PSA quantification. This device comprises a polymethyl methacrylate microfluidic platform coupled with electrochemical detection. The platinum working microelectrode was positioned in the outflow region of the microchannel and was modified with carbon nanofibers (CNF)-decorated gold nanoporous (GNP) structures by the dynamic hydrogen bubble template method, through the simultaneous electrodeposition of metal precursors in the presence of CNF. CNF/GNP structures exhibit attractive properties, such as a large surface to volume ratio, which increases the antibody's immobilization capacity and the electroactive area. CNFs/GNP structures were characterized by scanning electron microscopy, energy dispersive spectrometry, and cyclic voltammetry. Anti-PSA antibodies and HRP were employed for the immune-electrochemical reaction. The detection limit for the device was 5 pg mL

Indexed as

Biosensing TechniquesMetal NanoparticlesNanofibersNanoporesProstatic NeoplasmsCarbonElectrochemical TechniquesGoldHumansImmunoassayLimit of DetectionMaleMicrofluidicsProstate-Specific AntigenCarbonGoldProstate-Specific Antigencancer biomarkercarbon nanofiberselectrochemicalgold nanoporousimmunosensormicrofluidic

Identifiers

PMID36979602
PMCPMC10046291
OpenAlexW4327729862

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read40
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.