Evidence map›Paper›PMID 36979660›Full record

ArticleBiomedicines2023

In Vitro Pharmacokinetic Behavior of Antiviral 3-Amidinophenylalanine Derivatives in Rat, Dog and Monkey Hepatocytes.

Katalin Lányi, Katalin Monostory, Torsten Steinmetzer, Ákos Jerzsele, Erzsébet Pászti-Gere

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Katalin LányiDepartment of Food Hygiene, University of Veterinary Medicine, István utca 2, H-1078 Budapest, Hungary.ORCID 0000-0003-1992-6324
Katalin MonostoryResearch Centre for Natural Sciences, Institute of Enzymology, Magyar Tudósok 2, H-1117 Budapest, Hungary.ORCID 0000-0002-0861-1450
Torsten SteinmetzerDepartment of Pharmacy, Institute of Pharmaceutical Chemistry, Philipps University Marburg, Marbacher Weg 6, G-35032 Marburg, Germany.
Ákos JerzseleDepartment of Pharmacology and Toxicology, University of Veterinary Medicine, István utca 2, H-1078 Budapest, Hungary.ORCID 0000-0002-3380-0827
Erzsébet Pászti-GereDepartment of Pharmacology and Toxicology, University of Veterinary Medicine, István utca 2, H-1078 Budapest, Hungary.
University of Veterinary Medicine · HUInstitute of Molecular Life Sciences · HUPhilipps University of Marburg · DE

Funding

Recovery and Resilience Facility (RRF), financed under National Recovery Fund budget RRF-2.3.1-21-2022-00001
6 · The paper itself

Abstract

Type II transmembrane serine proteases represent pharmacological targets for blocking entry and spread of influenza or coronaviruses. In this study, the depletion rates of the 3-amidinophenylalanine (3-APhA)-derived matriptase/TMPRSS2 inhibitors MI-463, MI-472, MI-485 or MI-1900 were determined by LC-MS/MS measurements over a period of 300 min using suspensions of rat, dog and cynomolgus monkey primary hepatocytes. From these in vitro pharmacokinetic (PK) experiments, intrinsic clearance values (Cl

Indexed as

3-amidinophenylalanineantiviralcoronaviruscynomolgus monkeydepletion ratedogintrinsic clearancematriptaseratTMPRSS2

Identifiers

PMID36979660
PMCPMC10045298
OpenAlexW4321790284

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read19
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.