Evidence mapPaperPMID 36979690Full record

ReviewBiomedicines2023

HDL-Based Therapy: Vascular Protection at All Stages.

Anastasia V Poznyak, Vasily N Sukhorukov, Ilya I Eremin, Irina I Nadelyaeva, Nikita A Gutyrchik, Alexander N Orekhov

Open access · goldFull text readReview
In one paragraph

Review in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Anastasia V PoznyakInstitute for Atherosclerosis Research, Osennyaya 4-1-207, 121609 Moscow, Russia.ORCID 0000-0002-1516-1320
Vasily N SukhorukovInstitute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, 125315 Moscow, Russia.ORCID 0000-0002-0312-3773
Ilya I EreminPetrovsky National Research Centre of Surgery, 2, Abrikosovsky Lane, 119991 Moscow, Russia.
Irina I NadelyaevaPetrovsky National Research Centre of Surgery, 2, Abrikosovsky Lane, 119991 Moscow, Russia.
Nikita A GutyrchikPetrovsky National Research Centre of Surgery, 2, Abrikosovsky Lane, 119991 Moscow, Russia.
Alexander N OrekhovInstitute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, 125315 Moscow, Russia.ORCID 0000-0002-3318-4681
Russian Scientific Center of Surgery · RUResearch Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences · RUInstitute for Atherosclerosis Research · RU

Funding

Russian Science Foundation 22-65-00005
6 · The paper itself

Abstract

It is known that lipid metabolism disorders are involved in a wide range of pathologies. These pathologies include cardiovascular, metabolic, neurodegenerative diseases, and even cancer. All these diseases lead to serious health consequences, which makes it impossible to ignore them. Unfortunately, these diseases most often have a complex pathogenesis, which makes it difficult to study them and, in particular, diagnose and treat them. HDL is an important part of lipid metabolism, performing many functions under normal conditions. One of such functions is the maintaining of the reverse cholesterol transport. These functions are also implicated in pathology development. Thus, HDL contributes to vascular protection, which has been demonstrated in various conditions: Alzheimer's disease, atherosclerosis, etc. Many studies have shown that serum levels of HDL cholesterol correlate negatively with CV risk. With these data, HDL-C is a promising therapeutic target. In this manuscript, we reviewed HDL-based therapeutic strategies that are currently being used or may be developed soon.

Indexed as

ASCVDatherosclerosiscancercardiovascular diseaseCVDdiabetes mellitusHDL

Identifiers

PMID36979690
PMCPMC10045384
OpenAlexW4322500376

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read30
identifiers read3
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.