Evidence mapPaperPMID 36979781Full record

ReviewBiomedicines2023

Endothelial, Vascular and Sympathetic Alterations as Therapeutic Targets in Chronic Heart Failure.

Fosca Quarti-Trevano, Raffaella Dell'Oro, Cesare Cuspidi, Pasquale Ambrosino, Guido Grassi

Open access · goldFull text readReview
In one paragraph

Review in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Fosca Quarti-TrevanoClinica Medica, School of Medicine and Surgery, University Milano-Bicocca, 20052 Monza, Italy.ORCID 0000-0002-7357-0931
Raffaella Dell'OroClinica Medica, School of Medicine and Surgery, University Milano-Bicocca, 20052 Monza, Italy.ORCID 0000-0002-9812-2879
Cesare CuspidiClinica Medica, School of Medicine and Surgery, University Milano-Bicocca, 20052 Monza, Italy.
Pasquale AmbrosinoIstituti Clinici Scientifici Maugeri IRCCS, Directorate of Telese Terme Institute, 82037 Telese Terme, Italy.ORCID 0000-0002-9398-0428
Guido GrassiClinica Medica, School of Medicine and Surgery, University Milano-Bicocca, 20052 Monza, Italy.
University of Milano-Bicocca · ITIstituti Clinici Scientifici Maugeri · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vascular and sympathetic abnormalities characterize chronic heart failure (CHF). Alterations include (1) a reduction in arterial distensibility, (2) endothelial dysfunction, (3) a decrease in arterial compliance and a parallel increase in arterial stiffness, and (4) sympathetic cardiovascular activation. Altogether, these alterations represent important targets in therapeutic interventions, because they display an independent negative impact on the disease prognosis, favouring disease progression and the development of cardiovascular complications with direct and indirect mechanisms. The present review will examine the effects of the different therapeutic interventions targeting the vascular/sympathetic alterations detected in CHF. Non-pharmacological, pharmacological and device-based treatments will be discussed in detail, highlighting the possible mechanisms responsible for the vascular/sympathetic effects of each intervention. Finally, the unmet goals in treatment in relation to endothelial and adrenergic targets will be also discussed.

Indexed as

cardiovascular drugscarotid baroreceptor stimulationchronic heart failureendothelial functionphysical trainingrehabilitationrenal denervationsympathetic activity

Identifiers

PMID36979781
PMCPMC10044749
OpenAlexW4323361615

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read3
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.