Evidence map›Paper›PMID 36979849›Full record

ArticleBiomedicines2023

COVID-19 Associated Vasculitis Confirmed by the Tissues RT-PCR: A Case Series Report.

Konstantin E Belozerov, Ilia S Avrusin, Lyubov I Andaryanova, Anna M Guseva, Zaira S Shogenova, Irina N Belanovich, Anna V Lobacheva, Tatiana L Kornishina, Eugenia A Isupova, Vera V Masalova and 10 more

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 1 country.

Konstantin E BelozerovHospital Pediatry, Saint Petersburg State Pediatric Medical University, 194100 Saint Petersburg, Russia.ORCID 0000-0001-9598-1638
Ilia S AvrusinHospital Pediatry, Saint Petersburg State Pediatric Medical University, 194100 Saint Petersburg, Russia.ORCID 0000-0002-4919-0939
Lyubov I AndaryanovaHospital Pediatry, Saint Petersburg State Pediatric Medical University, 194100 Saint Petersburg, Russia.
Anna M GusevaHospital Pediatry, Saint Petersburg State Pediatric Medical University, 194100 Saint Petersburg, Russia.
Zaira S ShogenovaHospital Pediatry, Saint Petersburg State Pediatric Medical University, 194100 Saint Petersburg, Russia.
Irina N BelanovichHospital Pediatry, Saint Petersburg State Pediatric Medical University, 194100 Saint Petersburg, Russia.
Anna V LobachevaHospital Pediatry, Saint Petersburg State Pediatric Medical University, 194100 Saint Petersburg, Russia.
Tatiana L KornishinaHospital Pediatry, Saint Petersburg State Pediatric Medical University, 194100 Saint Petersburg, Russia.
Eugenia A IsupovaHospital Pediatry, Saint Petersburg State Pediatric Medical University, 194100 Saint Petersburg, Russia.
Vera V MasalovaHospital Pediatry, Saint Petersburg State Pediatric Medical University, 194100 Saint Petersburg, Russia.
Olga V KalashnikovaHospital Pediatry, Saint Petersburg State Pediatric Medical University, 194100 Saint Petersburg, Russia.
Andrey V NokhrinHospital Pediatry, Saint Petersburg State Pediatric Medical University, 194100 Saint Petersburg, Russia.
Tatyana F PanovaPediatric Department, Leningrad Regional Children's Clinical Hospital, 195009 Saint Petersburg, Russia.
Yulia P DutovaPediatric Department, Leningrad Regional Children's Clinical Hospital, 195009 Saint Petersburg, Russia.
Svetlana L MyshkovskayaPediatric Department, Leningrad Regional Children's Clinical Hospital, 195009 Saint Petersburg, Russia.
Kirill Y KostyuninPathology Department, Irkutsk State Medical University, 664003 Irkutsk, Russia.
Andrey B KomissarovLaboratory of Molecular Virology, Smorodintsev Research Institute of Influenza, 197376 Saint Petersburg, Russia.ORCID 0000-0003-1733-1255
Vyacheslav G ChasnykHospital Pediatry, Saint Petersburg State Pediatric Medical University, 194100 Saint Petersburg, Russia.
Liudmila V BregelDepartment of Pediatrics, Irkutsk State Medical Academy of Postgraduate Education, Branch of Russian Medical Academy of Continuous Professional Education, 664049 Irkutsk, Russia.
Mikhail M KostikHospital Pediatry, Saint Petersburg State Pediatric Medical University, 194100 Saint Petersburg, Russia.ORCID 0000-0002-1180-8086
Saint Petersburg State Pediatric Medical University · RULeningrad Regional Cancer Center · RUIrkutsk Regional Clinical Hospital · RUResearch Institute of Influenza · RURussian Medical Academy of Continuous Professional Education · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeveral cases of skin and central nervous system vasculopathy associated with COVID-19 in children have been published, but the information is rather limited. Our study aimed to describe these cases of vasculitis associated with COVID-19 in children.

methodsIn the retrospective-prospective case series study we included information regarding four children with COVID-19-associated vasculitis. In every case, we had a morphological description and the etiology was confirmed via real-time polymerase chain reaction during a tissue biopsy.

resultsThe most involved systems were skin (4/4), respiratory (3/4), cardiovascular (2/4), nervous (1/4), eye (1/4), kidney (1/4), and inner year (1/4). All patients had increased inflammatory markers and thrombotic parameters (D-dimer). No patient met the criteria for multisystem inflammatory syndrome in children. Two patients met polyarteritis nodosa criteria, one met Henoch-Schonlein purpura criteria, and one met unclassified vasculitis criteria. All patients were treated with systemic glucocorticosteroids (two-pulse therapy). Non-biologic DMARDs were prescribed in all cases; 1/4 patients (25%) was treated with intravenous immunoglobuline, and 3/4 (75%) were treated with biologics (etanercept, tocilizumab, and adalimumab).

conclusionsVasculitis associated with COVID-19 could be a life-threatening condition; SARS-CoV-2 might be a new trigger or etiological agent for vasculitis and other immune-mediated diseases. Further research and collection of similar cases are required.

Indexed as

childhood vasculitisCOVID-19Henoch–Schonlein purpuraIg A vasculopathymesenteric thrombosispolyarteritis nodosareal-time PCRSARS-CoV-2vasculopathy

Identifiers

PMID36979849
PMCPMC10046188
OpenAlexW4324054708

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read8
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.