Evidence map›Paper›PMID 36979888›Full record

ArticleBiomedicines2023

Characterization of T Helper 1 and 2 Cytokine Profiles in Newborns of Mothers with COVID-19.

André Luís Elias Moreira, Paulo Alex Neves da Silva, Rodrigo Saar Gomes, Mônica de Oliveira Santos, Célia Regina Malveste Ito, Lucas Candido Gonçalves Barbosa, Paula Pires de Souza, Fernanda Aparecida de Oliveira Peixoto, Isabela Jubé Wastowski, Lilian Carla Carneiro and 1 more

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

André Luís Elias MoreiraMicroorganism Biotechnology Laboratory, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia 74605-050, Brazil.
Paulo Alex Neves da SilvaMicroorganism Biotechnology Laboratory, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia 74605-050, Brazil.ORCID 0000-0002-0675-9873
Rodrigo Saar GomesNatural Immunity Laboratory, Institute of Tropical Pathology and Public Health, Federal University of Goiás, St. 235, Setor Leste Universitário, Goiânia 74605-050, Brazil.ORCID 0000-0001-9551-9419
Mônica de Oliveira SantosMicroorganism Biotechnology Laboratory, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia 74605-050, Brazil.ORCID 0000-0001-7110-5430
Célia Regina Malveste ItoMicroorganism Biotechnology Laboratory, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia 74605-050, Brazil.
Lucas Candido Gonçalves BarbosaMicroorganism Biotechnology Laboratory, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia 74605-050, Brazil.ORCID 0000-0001-7246-9359
Paula Pires de SouzaNeonatology of Children's Hospital, St. 86, 160 St. Sul, Goiânia 74083-330, Brazil.
Fernanda Aparecida de Oliveira PeixotoNeonatal Intensive Care Unit (NICU), Hospital das Clínicas, Federal University of Goiás, Goiânia 74605-020, Brazil.
Isabela Jubé WastowskiMolecular Immunology Laboratory, Goiás State University, Laranjeiras Campus, St. Prof. Alfredo de Castro, 9175, Parque das Laranjeiras, Goiânia 74855-130, Brazil.
Lilian Carla CarneiroMicroorganism Biotechnology Laboratory, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia 74605-050, Brazil.
Melissa Ameloti Gomes AvelinoMicroorganism Biotechnology Laboratory, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia 74605-050, Brazil.ORCID 0000-0003-0342-0978
Universidade Federal de Goiás · BRUniversidade Estadual de Goiás · BR

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior 0678/2020/88881.504906/2020-01
6 · The paper itself

Abstract

An infectious disease caused by SARS-CoV-2, COVID-19 greatly affects the pediatric population and is 3 times more prevalent in newborns than in the general population. In newborns, the overexpression of immunological molecules may also induce a so-called cytokine storm. In our study, we evaluated the expression of cytokines in newborns admitted to a neonatal ICU whose mothers had SARS-CoV-2 and symptoms of SARS. The blood of newborns of infected and healthy mothers was collected to identify their Th1 and Th2 cytokine profiles, and via flow cytometry, the cytokines TNF-α, IFN-γ, IL-2, IL-6, and IL-10 were identified. Overexpression was observed in the Th1 and Th2 cytokine profiles of newborns from infected mothers compared with the control group. Statistical analysis also revealed significant differences between the cellular and humoral responses of the infected group versus the control group. The cellular versus humoral responses of the newborns of infected mothers were also compared, which revealed the prevalence of the cellular immune response. These data demonstrate that some cytokines identified relate to more severe symptoms and even some comorbidities. IL-6, TNF-α, and IL-10 may especially be related to cytokine storms in neonates of mothers with COVID-19.

Indexed as

comorbidityCOVID-19cytokine stormmothernewbornSARS

Identifiers

PMID36979888
PMCPMC10045352
OpenAlexW4324356435

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read44
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.