Evidence map›Paper›PMID 36980241›Full record

ReviewCells2023

Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1.

Yagmur Kan, YiTing Paung, Markus A Seeliger, W Todd Miller

Open access · goldFull text readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Yagmur KanDepartment of Physiology and Biophysics, School of Medicine, Stony Brook University, Stony Brook, NY 11794-8661, USA.ORCID 0000-0002-7127-1356
YiTing PaungDepartment of Pharmacology, School of Medicine, Stony Brook University, Stony Brook, NY 11794-8661, USA.
Markus A SeeligerDepartment of Pharmacology, School of Medicine, Stony Brook University, Stony Brook, NY 11794-8661, USA.ORCID 0000-0003-0990-1756
W Todd MillerDepartment of Physiology and Biophysics, School of Medicine, Stony Brook University, Stony Brook, NY 11794-8661, USA.
Stony Brook University · USNorthport VA Medical Center · US

Funding

Dynamics of Ligand Binding and Protein Kinase Regulation_RenewalR35GM119437 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI Markus A Seeliger · 2016 to 2026
$6.5M
Nonreceptor tyrosine kinases in Systemic Lupus ErythematosusR01AI164424 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI MILLER, W TODD · 2021 to 2025
$1.6M
BLRD VA I01 BX002292NIAID NIH HHS R01 AI164424NIGMS NIH HHS R35 GM119437NIH HHS R01 AI164424
6 · The paper itself

Abstract

The nonreceptor tyrosine kinase (NRTK) Ack1 comprises a distinct arrangement of non-catalytic modules. Its SH3 domain has a C-terminal to the kinase domain (SH1), in contrast to the typical SH3-SH2-SH1 layout in NRTKs. The Ack1 is the only protein that shares a region of high homology to the tumor suppressor protein Mig6, a modulator of EGFR. The vertebrate Acks make up the only tyrosine kinase (TK) family known to carry a UBA domain. The GTPase binding and SAM domains are also uncommon in the NRTKs. In addition to being a downstream effector of receptor tyrosine kinases (RTKs) and integrins, Ack1 can act as an epigenetic regulator, modulate the degradation of the epidermal growth factor receptor (EGFR), confer drug resistance, and mediate the progression of hormone-sensitive tumors. In this review, we discuss the domain architecture of Ack1 in relation to other protein kinases that possess such defined regulatory domains.

Indexed as

ErbB ReceptorsProtein-Tyrosine KinasesProtein DomainsReceptor Protein-Tyrosine Kinasessrc Homology DomainsErbB ReceptorsProtein-Tyrosine KinasesReceptor Protein-Tyrosine KinasesTNK2 protein, humanAck1activated Cdc42-associated kinasenonreceptor tyrosine kinaseSAM domainubiquitin-associated domain

Identifiers

PMID36980241
PMCPMC10047419
OpenAlexW4324361281

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read26
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.