Evidence map›Paper›PMID 36980889›Full record

ArticleGenes2023

Missense Variants of von Willebrand Factor in the Background of COVID-19 Associated Coagulopathy.

Zsuzsanna Elek, Eszter Losoncz, Katalin Maricza, Zoltán Fülep, Zsófia Bánlaki, Réka Kovács-Nagy, Gergely Keszler, Zsolt Rónai

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Zsuzsanna ElekInstitute of Biochemistry and Molecular Biology, Department of Molecular Biology, Semmelweis University, 1085 Budapest, Hungary.
Eszter LosonczDepartment of Anesthesiology and Intensive Therapy, Bács-Kiskun County Teaching Hospital, 6000 Kecskemét, Hungary.ORCID 0000-0001-6426-8821
Katalin MariczaInstitute of Biochemistry and Molecular Biology, Department of Molecular Biology, Semmelweis University, 1085 Budapest, Hungary.
Zoltán FülepDepartment of Anesthesiology and Intensive Therapy, Bács-Kiskun County Teaching Hospital, 6000 Kecskemét, Hungary.
Zsófia BánlakiInstitute of Biochemistry and Molecular Biology, Department of Molecular Biology, Semmelweis University, 1085 Budapest, Hungary.
Réka Kovács-NagyInstitute of Biochemistry and Molecular Biology, Department of Molecular Biology, Semmelweis University, 1085 Budapest, Hungary.
Gergely KeszlerInstitute of Biochemistry and Molecular Biology, Department of Molecular Biology, Semmelweis University, 1085 Budapest, Hungary.
Zsolt RónaiInstitute of Biochemistry and Molecular Biology, Department of Molecular Biology, Semmelweis University, 1085 Budapest, Hungary.ORCID 0000-0002-0909-7932
Semmelweis University · HUBács-Kiskun Megyei Kórház · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

COVID-19 associated coagulopathy (CAC), characterized by endothelial dysfunction and hypercoagulability, evokes pulmonary immunothrombosis in advanced COVID-19 cases. Elevated von Willebrand factor (vWF) levels and reduced activities of the ADAMTS13 protease are common in CAC. Here, we aimed to determine whether common genetic variants of these proteins might be associated with COVID-19 severity and hemostatic parameters. A set of single nucleotide polymorphisms (SNPs) in the

Indexed as

Blood Coagulation DisordersCOVID-19von Willebrand FactorCross-Sectional StudiesHumansMutation, MissensePolymorphism, Single Nucleotidevon Willebrand FactorADAMTS13COVID-19 associated coagulopathyimmunothrombosismissense variantprotein conformationsingle nucleotide polymorphism (SNP)von Willebrand factor

Identifiers

PMID36980889
PMCPMC10048626
OpenAlexW4322741745

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read30
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.