Evidence map›Paper›PMID 36982172›Full record

ArticleInternational journal of molecular sciences2023

An 8q24 Gain in Pancreatic Juice Is a Candidate Biomarker for the Detection of Pancreatic Cancer.

Iris J M Levink, Malgorzata I Srebniak, Walter G De Valk, Monique M van Veghel-Plandsoen, Anja Wagner, Djuna L Cahen, Gwenny M Fuhler, Marco J Bruno

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Iris J M LevinkDepartment of Gastroenterology & Hepatology, Erasmus MC, University Medical Center, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0001-9825-8728
Malgorzata I SrebniakDepartment of Clinical Genetics, Erasmus MC, University Medical Center, 3015 CN Rotterdam, The Netherlands.ORCID 0000-0003-3429-6156
Walter G De ValkDepartment of Clinical Genetics, Erasmus MC, University Medical Center, 3015 CN Rotterdam, The Netherlands.
Monique M van Veghel-PlandsoenDepartment of Clinical Genetics, Erasmus MC, University Medical Center, 3015 CN Rotterdam, The Netherlands.
Anja WagnerDepartment of Clinical Genetics, Erasmus MC, University Medical Center, 3015 CN Rotterdam, The Netherlands.
Djuna L CahenDepartment of Gastroenterology & Hepatology, Erasmus MC, University Medical Center, 3015 GD Rotterdam, The Netherlands.
Gwenny M FuhlerDepartment of Gastroenterology & Hepatology, Erasmus MC, University Medical Center, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0001-9221-4855
Marco J BrunoDepartment of Gastroenterology & Hepatology, Erasmus MC, University Medical Center, 3015 GD Rotterdam, The Netherlands.
Erasmus MC · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Secretin-stimulated pancreatic juice (PJ), collected from the duodenum, presents a valuable biomarker source for the (earlier) detection of pancreatic cancer (PC). Here, we evaluate the feasibility and performance of shallow sequencing to detect copy number variations (CNVs) in cell-free DNA (cfDNA) from PJ for PC detection. First, we confirmed the feasibility of shallow sequencing in PJ (n = 4), matched plasma (n = 3) and tissue samples (n = 4, microarray). Subsequently, shallow sequencing was performed on cfDNA from PJ of 26 cases (25 sporadic PC, 1 high-grade dysplasia) and 19 controls with a hereditary or familial increased risk of PC. 40 of the 45 PJ samples met the quality criteria for cfDNA analysis. Nine individuals had an 8q24 gain (oncogene MYC; 23%; eight cases (33%) and one control (6%),

Indexed as

Cell-Free Nucleic AcidsPancreatic NeoplasmsBiomarkersBiomarkers, TumorDNA Copy Number VariationsHumansPancreatic JuiceBiomarkersBiomarkers, TumorCell-Free Nucleic AcidscfDNACNVcopy number variantliquid biopsyNIPT

Identifiers

PMID36982172
PMCPMC10049288
OpenAlexW4323567975

What Socratic holds

Textfull text, public
LicenceCC BY
reference markers read1
measurements read96
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.