ReviewInternational journal of molecular sciences2023
To Predict, Prevent, and Manage Post-Traumatic Stress Disorder (PTSD): A Review of Pathophysiology, Treatment, and Biomarkers.
Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Colors of the mind: a meta-analysis of creative arts therapy as an approach for post-traumatic stress disorder intervention.BMC psychology · 2025Pooled it
- Pooled it
- Biological treatments for co-occurring eating disorders and psychological trauma: a systematic review.Frontiers in psychiatry · 2025Pooled it
- A quick review of infrared thermography studies on children and adolescents' mental health.Frontiers in psychiatry · 2025Pooled it
- 3MDR Therapy Reduces Symptoms of PTSD and Related Conditions in Canadian Military Members and Veterans, Public Safety Personnel, and Clinical Personnel.Brain and behavior · 2026Trial
- Endocannabinoid and N-acylethanolamine concentrations in hair of female patients with posttraumatic stress disorder - associations with clinical symptoms and outcomes following multimodal trauma-focused inpatient treatment.Translational psychiatry · 2025Trial
- The microbiome and PTSD: a scoping review across preclinical and clinical studies.European journal of psychotraumatology · 2026Article
- Investigation of the effects of two exercise protocols on behavioral and biochemical changes in ovariectomized rats exposed to single prolonged stress.IBRO neuroscience reports · 2026Article
- Treatment of posttraumatic stress disorder (PTSD).Dialogues in clinical neuroscience · 2026Review
- Selective Dopamine Transporter Inhibition with CE-123 Promotes Fear Extinction and Alters the Basolateral Amygdala Proteome Following Fear Extinction in Adolescent Male Rats.International journal of molecular sciences · 2026Article
- Severity-dependent changes in hippocampal necroptosis markers and neuronal loss in a PTSD-like mouse model: potential involvement of nitric oxide signaling.Psychopharmacology · 2026Article
- Predicting Probable Persistent PTSD Following the Sewol Ferry Disaster: Development of an AI Algorithm Based on Psychological Assessments and Biological Markers.Psychiatry investigation · 2026Article
- Pre-diagnostic biomarkers and risk of stress-related disorders: a cohort study based on electronic health records.BMC medicine · 2026Article
- Actionable medications in Australian Vietnam War veterans: Implications for pre-emptive pharmacogenetic testing.Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists · 2026Article
- Role of Intelligence in Posttraumatic Stress Disorder Development: A Systematic Review.Journal of Intelligence · 2026Review
- Multilayered regulation of BDNF DNA methylation in PTSD: a review from molecular mechanisms to trans generational inheritance.Frontiers in psychiatry · 2026Review
- Neuromodulatory Effects of Alternating Current Electroacupuncture on PTSD-like Behaviors via Gut-Brain Axis Communication.Brain sciences · 2025Article
- Serum Cortisol and Interleukin-6 as Key Biomarkers for a Diagnostic Algorithm of Combat-Related PTSD.Brain sciences · 2025Article
- War, diet, and PTSD in Ukrainian youth.Scientific reports · 2025Article
- PET imaging evidence of HDAC6 suppression in the amygdala across species in PTSD.Molecular psychiatry · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Post-traumatic stress disorder (PTSD) can become a chronic and severely disabling condition resulting in a reduced quality of life and increased economic burden. The disorder is directly related to exposure to a traumatic event, e.g., a real or threatened injury, death, or sexual assault. Extensive research has been done on the neurobiological alterations underlying the disorder and its related phenotypes, revealing brain circuit disruption, neurotransmitter dysregulation, and hypothalamic-pituitary-adrenal (HPA) axis dysfunction. Psychotherapy remains the first-line treatment option for PTSD given its good efficacy, although pharmacotherapy can also be used as a stand-alone or in combination with psychotherapy. In order to reduce the prevalence and burden of the disorder, multilevel models of prevention have been developed to detect the disorder as early as possible and to reduce morbidity in those with established diseases. Despite the clinical grounds of diagnosis, attention is increasing to the discovery of reliable biomarkers that can predict susceptibility, aid diagnosis, or monitor treatment. Several potential biomarkers have been linked with pathophysiological changes related to PTSD, encouraging further research to identify actionable targets. This review highlights the current literature regarding the pathophysiology, disease development models, treatment modalities, and preventive models from a public health perspective, and discusses the current state of biomarker research.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.