ReviewInternational journal of molecular sciences2023
Drug-Induced Gingival Overgrowth-Molecular Aspects of Drug Actions.
Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Non-surgical treatment of cyclosporin A-induced gingival overgrowth: A systematic review and meta-analysis.Medicine · 2025Pooled it
- Drug-induced gingival overgrowth: evaluation of an online survey.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Association between salivary microbiota-related amino acid metabolic dysregulation and tacrolimus-induced gingival overgrowth following kidney transplantation.BMC oral health · 2026Article
- Early prediction of orthodontic gingival enlargement using S100A4: a biomarker-based risk stratification model.Odontology · 2026Article
- Voclosporin-induced gingival enlargement: A case report.Clinical advances in periodontics · 2026Article
- Anti-Proliferative Effects of Resveratrol on Gingival Fibroblasts Derived From Amlodipine-Induced Gingival Overgrowth.Journal of periodontal research · 2026Article
- Social media data and its potential for pharmacovigilance: a comparative analysis of reported prevalences regarding drug-induced gingival overgrowth (DIGO).Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Variations between package inserts regarding gingival overgrowth causing drugs.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Histomorphometric and immunohistochemical evaluation of apoptosis in nifedipine-induced gingival overgrowth.BMC oral health · 2026Article
- Drug-Induced Gingival Enlargement: A Comparative Study on the Effect of Phenytoin, Gabapentin, and Cyclosporin on Gingival Fibroblast Cells.Molecular biotechnology · 2026Article
- Association of anxiety and depression with oral health status of pregnant women attending antenatal care clinics at a tertiary care hospital, Karachi: a study protocol.BMJ public health · 2026Article
- Drug-induced gingival overgrowth: FAERS based real-world pharmacovigilance study and network pharmacology analysis.Frontiers in pharmacology · 2026Article
- Nifedipine Induces FAM20A Upregulation and LRP2/CUBN-Mediated Fetuin-A Accumulation in Gingival Overgrowth.International journal of dentistry · 2026Article
- Drug-induced gingival overgrowth in renal transplants patients.Open medicine (Warsaw, Poland) · 2026Review
- Histopathological and Molecular Characterization of Amlodipine-Induced Gingival Enlargement: Insights into Fibrotic Mechanisms.Pharmaceuticals (Basel, Switzerland) · 2025Article
- The Systemic Link Between Oral Health and Cardiovascular Disease: Contemporary Evidence, Mechanisms, and Risk Factor Implications.Diseases (Basel, Switzerland) · 2025Review
- Initial periodontal therapy for seven patients with aplastic anemia and drug-induced gingival overgrowth: a case series report.BMC oral health · 2025Article
- Identifying Key Factors in Papilla Growth Around Implants: Focus on Intraoral Negative Pressure.Dentistry journal · 2025Article
- Calcium Antagonist-Induced Gingival Overgrowth: A Case Report and Literature Review.Diagnostics (Basel, Switzerland) · 2025Article
- Effects of combined cyclosporin and azithromycin treatment on human mononuclear cells under lipopolysaccharide challenge.Frontiers in oral health · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drug-induced gingival overgrowth (DIGO) is one of the side effects produced by therapeutic agents, most commonly phenytoin, nifedipine and cyclosporin A. However, the precise mechanism of DIGO is not entirely understood. A literature search of the MEDLINE/PubMed databases was conducted to identify the mechanisms involved in DIGO. The available information suggests that the pathogenesis of DIGO is multifactorial, but common pathogenic sequelae of events emerge, i.e., sodium and calcium channel antagonism or disturbed intracellular handling of calcium, which finally lead to reductions in intracellular folic acid levels. Disturbed cellular functions, mainly in keratinocytes and fibroblasts, result in increased collagen and glycosaminoglycans accumulation in the extracellular matrix. Dysregulation of collagenase activity, as well as integrins and membrane receptors, are key mechanisms of reduced degradation or excessive synthesis of connective tissue components. This manuscript describes the cellular and molecular factors involved in the epithelial-mesenchymal transition and extracellular matrix remodeling triggered by agents producing DIGO.
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.