Evidence map›Paper›PMID 36983607›Full record

ArticleJournal of personalized medicine2023

Targeting mTOR Pathway in PTEN Deleted Newly Isolated Chordoma Cell Line.

Francesca Pagani, Magdalena Gryzik, Elena Somenza, Manuela Cominelli, Piera Balzarini, Alberto Schreiber, Davide Mattavelli, Piero Nicolai, Francesco Doglietto, Pietro Luigi Poliani

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of personalized medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Francesca PaganiPathology Unit, Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0002-1671-5671
Magdalena GryzikPathology Unit, Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
Elena SomenzaPathology Unit, Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
Manuela CominelliPathology Unit, Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
Piera BalzariniPathology Unit, Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
Alberto SchreiberUnit of Otorhinolaryngology-Head and Neck Surgery, ASST Spedali Civili Brescia, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, 25123 Brescia, Italy.
Davide MattavelliUnit of Otorhinolaryngology-Head and Neck Surgery, ASST Spedali Civili Brescia, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0001-7023-6746
Piero NicolaiSection of Otorhinolaryngology-Head and Neck Surgery, Department of Neurosciences, University of Padova-Azienda Ospedale-Università di Padova, 35128 Padova, Italy.
Francesco DogliettoFondazione Policlinico Universitario Agostino Gemelli IRCCS, Catholic University School of Medicine, 00168 Rome, Italy.ORCID 0000-0002-7438-0734
Pietro Luigi PolianiPathology Unit, Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0002-5662-8978
University of Brescia · ITAgostino Gemelli University Polyclinic · ITUniversity of Padua · IT

Funding

Associazione dedicato A te private foundationFondazione camillo golgi Private foundation
6 · The paper itself

Abstract

Chordomas are rare primary malignant tumours of notochordal origin usually arising along the axial skeleton with particular predilection of the skull base and sacrococcygeal region. Albeit usually slow-growing, chordomas can be aggressive mostly depending on their invasive behaviour and according to different histotypes and molecular alterations, including

Indexed as

CH3 cell linechordomamTORrapamycin

Identifiers

PMID36983607
PMCPMC10056194
OpenAlexW4322500707

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.