Evidence map›Paper›PMID 36984845›Full record

ArticleMetabolites2023

Multi-Omics Analysis of Lung Tissue Demonstrates Changes to Lipid Metabolism during Allergic Sensitization in Mice.

Kedir N Turi, Cole R Michel, Jonathan Manke, Katrina A Doenges, Nichole Reisdorph, Alison K Bauer

Open access · goldAbstract read
In one paragraph

Article in Metabolites, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Murine Alox8 versus the human ALOX15B ortholog: differences and similarities.Pflugers Archiv : European journal of physiology · 2024
    Review
  9. Article
  10. Review
  11. Carotenoids in Health as Studied by Omics-Related Endpoints.Advances in nutrition (Bethesda, Md.) · 2023
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Kedir N TuriDepartment of Medicine, Vanderbilt University, Nashville, TN 37203, USA.ORCID 0000-0002-3853-9357
Cole R MichelDepartment of Pharmaceutical Sciences, University of Colorado, Aurora, CO 80045, USA.
Jonathan MankeDepartment of Pharmaceutical Sciences, University of Colorado, Aurora, CO 80045, USA.
Katrina A DoengesDepartment of Pharmaceutical Sciences, University of Colorado, Aurora, CO 80045, USA.
Nichole ReisdorphDepartment of Pharmaceutical Sciences, University of Colorado, Aurora, CO 80045, USA.ORCID 0000-0002-0425-8012
Alison K BauerDepartment of Environmental and Occupational Health, University of Colorado, Aurora, CO 80045, USA.ORCID 0000-0003-4477-9899
University of Colorado Anschutz Medical Campus · USVanderbilt University · US

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
PRIDE Academy: Impact of Ancestry and Gender to omics of lung diseasesR25HL146166 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Matthew Wayne DeCamp, Sonia Castro Flores · 2019 to 2026
$3.4M
Improved Prediction of Response to Asthma Medication Using Small MoleculesR01HL123385 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI REISDORPH, NICHOLE A · 2014 to 2017
$1.8M
Identification of Early Metabolomic and Immune Endotypes of Allergy and Asthma: An Integrated Multiomics ApproachK01HL149989 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI TURI, KEDIR NESHA · 2020 to 2024
$810k
Sensitive Triple Quadrupole Mass Spectrometer for Translational ResearchS10OD010366 · OD · NATIONAL JEWISH HEALTH · PI REISDORPH, NICHOLE A · 2012 to 2012
$443k
NCI NIH HHS P30 CA046934NHLBI NIH HHS K01 HL149989NHLBI NIH HHS R01 HL123385NHLBI NIH HHS R25 HL146166NIH HHS 1S10OD010366-01A1NIH HHS K01 HL149989NIH HHS P30CA046934NIH HHS R01HL123385NIH HHS R25HL146166NIH HHS S10 OD010366
6 · The paper itself

Abstract

Allergy and asthma pathogenesis are associated with the dysregulation of metabolic pathways. To understand the effects of allergen sensitization on metabolic pathways, we conducted a multi-omics study using BALB/cJ mice sensitized to house dust mite (HDM) extract or saline. Lung tissue was used to perform untargeted metabolomics and transcriptomics while both lung tissue and plasma were used for targeted lipidomics. Following statistical comparisons, an integrated pathway analysis was conducted. Histopathological changes demonstrated an allergic response in HDM-sensitized mice. Untargeted metabolomics showed 391 lung tissue compounds were significantly different between HDM and control mice (adjusted

Indexed as

allergyasthmahouse dust mitelipidomicsmetabolomicsmulti-omicsoxylipinstranscriptomics

Identifiers

PMID36984845
PMCPMC10054742
OpenAlexW4323846095

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.