Evidence map›Paper›PMID 36985262›Full record

ArticleMicroorganisms2023

Alterations in the Expression of IFN Lambda, IFN Gamma and Toll-like Receptors in Severe COVID-19 Patients.

Leonardo Sorrentino, Matteo Fracella, Federica Frasca, Alessandra D'Auria, Letizia Santinelli, Luca Maddaloni, Ginevra Bugani, Camilla Bitossi, Massimo Gentile, Giancarlo Ceccarelli and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Modulation ofFrontiers in immunology · 2025
    Article
  5. IFN Lambda Deficiency Contributes to Severe COVID-19 Outcomes.International journal of molecular sciences · 2024
    Article
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Leonardo SorrentinoLaboratory of Virology, Department of Molecular Medicine, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0003-3804-2946
Matteo FracellaLaboratory of Virology, Department of Molecular Medicine, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-2885-2382
Federica FrascaLaboratory of Virology, Department of Molecular Medicine, Sapienza University of Rome, 00185 Rome, Italy.
Alessandra D'AuriaLaboratory of Virology, Department of Molecular Medicine, Sapienza University of Rome, 00185 Rome, Italy.
Letizia SantinelliDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Policlinico Umberto I of Rome, 00185 Rome, Italy.ORCID 0000-0002-5621-058X
Luca MaddaloniDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Policlinico Umberto I of Rome, 00185 Rome, Italy.ORCID 0000-0002-9670-3135
Ginevra BuganiDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Policlinico Umberto I of Rome, 00185 Rome, Italy.
Camilla BitossiLaboratory of Virology, Department of Molecular Medicine, Sapienza University of Rome, 00185 Rome, Italy.
Massimo GentileLaboratory of Virology, Department of Molecular Medicine, Sapienza University of Rome, 00185 Rome, Italy.
Giancarlo CeccarelliDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Policlinico Umberto I of Rome, 00185 Rome, Italy.ORCID 0000-0001-5921-3180
Ombretta TurrizianiLaboratory of Virology, Department of Molecular Medicine, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-6400-9168
Claudio Maria MastroianniDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Policlinico Umberto I of Rome, 00185 Rome, Italy.ORCID 0000-0002-1286-467X
Guido AntonelliLaboratory of Virology, Department of Molecular Medicine, Sapienza University of Rome, 00185 Rome, Italy.
Gabriella d'EttorreDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Policlinico Umberto I of Rome, 00185 Rome, Italy.ORCID 0000-0002-3571-5677
Alessandra PierangeliLaboratory of Virology, Department of Molecular Medicine, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0003-0633-360X
Carolina ScagnolariLaboratory of Virology, Department of Molecular Medicine, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0003-1044-1478
Sapienza University of Rome · ITPoliclinico Umberto I · ITIstituto Pasteur · IT

Funding

a research grant to Scagnolari Carolina from Sapienza University of Rome, Progetti Ricerca- Progetti Medi, 2022 RM1221814ED155C3EU funding within the NextGeneration EU-MUR PNRR 326 Extended Partnership initiative on Emerging Infectious Diseases Project no. PE00000007, INF-ACT, 327 Spoke 1, 2 and 4
6 · The paper itself

Abstract

Contradictory results have been reported regarding interferon (IFN) lambda (λ1-3) and IFN gamma (γ) production in COVID-19 patients. To gain insight into the roles played by these IFNs in SARS-CoV-2 infection, IFNλ1-3 and IFNγ mRNA expression was evaluated in peripheral blood mononuclear cells (PBMCs) (

Indexed as

COVID-19immunologyinterferon

Identifiers

PMID36985262
PMCPMC10058642
OpenAlexW4323569590

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.