Evidence mapPaperPMID 36986122Full record

ArticleNutrients2023

Soy Extract, Rich in Hydroxylated Isoflavones, Exhibits Antidiabetic Properties In Vitro and in

Kai Lüersen, Alexandra Fischer, Ilka Bauer, Patricia Huebbe, Yukiko Uekaji, Keita Chikamoto, Daisuke Nakata, Naoto Hiramatsu, Keiji Terao, Gerald Rimbach

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
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  4. Review
  5. A comprehensiveFrontiers in pharmacology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kai LüersenInstitute of Human Nutrition and Food Science, University of Kiel, 24118 Kiel, Germany.ORCID 0000-0001-5812-1196
Alexandra FischerInstitute of Human Nutrition and Food Science, University of Kiel, 24118 Kiel, Germany.
Ilka BauerInstitute of Human Nutrition and Food Science, University of Kiel, 24118 Kiel, Germany.
Patricia HuebbeInstitute of Human Nutrition and Food Science, University of Kiel, 24118 Kiel, Germany.
Yukiko UekajiCycloChem Bio Co., Ltd., 7-4-5 Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Hyogo, Japan.
Keita ChikamotoCycloChem Bio Co., Ltd., 7-4-5 Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Hyogo, Japan.
Daisuke NakataCycloChem Bio Co., Ltd., 7-4-5 Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Hyogo, Japan.
Naoto HiramatsuToyo Hakko Co., Ltd., 1-39-1 Yoshikawa-cho, Obu-shi 474-0046, Aichi, Japan.
Keiji TeraoCycloChem Bio Co., Ltd., 7-4-5 Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Hyogo, Japan.ORCID 0000-0001-6563-095X
Gerald RimbachInstitute of Human Nutrition and Food Science, University of Kiel, 24118 Kiel, Germany.ORCID 0000-0001-7888-4684

Funding

Cyclochem Bio Co., Ltd (Japan) 2020-003
6 · The paper itself

Abstract

In the context of the growing prevalence of type 2 diabetes (T2DM), control of postprandial hyperglycemia is crucial for its prevention. Blood glucose levels are determined by various factors including carbohydrate hydrolyzing enzymes, the incretin system and glucose transporters. Furthermore, inflammatory markers are recognized predictors of diabetes outcome. Although there is some evidence that isoflavones may exhibit anti-diabetic properties, little is known about to what extent their corresponding hydroxylated metabolites may affect glucose metabolism. We evaluated the ability of a soy extract before (pre-) and after (post-) fermentation to counteract hyperglycemia in vitro and in

Indexed as

Diabetes Mellitus, Type 2HyperglycemiaIsoflavonesAnimalsDrosophila melanogasterFemaleGlucoseHypoglycemic AgentsPlant ExtractsGlucoseHypoglycemic AgentsIsoflavonesPlant Extractsbioactivityglucose metabolismhydroxy isoflavonesisoflavonessoy

Identifiers

PMID36986122
PMCPMC10054920
OpenAlexW4324148911

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.